Blood-contacting devices, including vascular stents, catheters and extracorporeal membrane oxygenation (ECMO), often lead to complications such as thrombosis, inflammation and infections, resulting in implantation failure and adverse events in clinical applications. In this study, a facile and universal antifouling coating with superhydrophobic properties was proposed to improve the contacting interface for combating thrombosis and bacterial infections. The fabrication of the coating was based on Fenton reaction and silane coupling. Oxidative groups were introduced after Fenton activation and topological structure was constructed on the surface by silane coupling agents, and fluoride was used for modification. The obtained superhydrophobic coatings appeared as compact and uniform nanofibers that possessed good resistance to protein adsorption and platelet adhesion, while the thrombus formation was inhibited. In addition, the adhesion of Staphylococcus aureus and Escherichia coli was effectively prevented, which potentially delayed the formation of biofilm and reduced the risk of infections. The coating was applicable to a variety of substrates (polymer, non-metallic inorganic and metallic) and the superhydrophobic properties were preserved after immersion in PBS for 28 days, indicating that it was a promising antithrombotic and antibacterial candidate for modification of medical devices.

血液接触设备，包括血管支架、导管和体外膜肺氧合（ECMO），经常导致血栓形成、炎症和感染等并发症，导致植入失败和临床应用中的不良事件。在这项研究中，提出了一种具有超疏水特性的简便通用的防污涂层，以改善接触界面以对抗血栓形成和细菌感染。涂层的制备基于芬顿反应和硅烷偶联。Fenton活化后引入氧化基团，通过硅烷偶联剂在表面构建拓扑结构，并使用氟化物进行修饰。所获得的超疏水涂层呈致密均匀的纳米纤维，具有良好的抗蛋白质吸附和血小板粘附能力，同时抑制血栓形成。此外，有效防止了金黄色葡萄球菌和大肠杆菌的粘附，有可能延缓生物膜的形成，降低感染风险。该涂层适用于多种基材（聚合物、非金属无机和金属），在 PBS 中浸泡 28 天后仍保持超疏水性能，表明它是一种很有前途的抗血栓和抗菌医疗器械修饰候选物。这可能会延迟生物膜的形成并降低感染的风险。该涂层适用于多种基材（聚合物、非金属无机和金属），在 PBS 中浸泡 28 天后仍保持超疏水性能，表明它是一种很有前途的抗血栓和抗菌医疗器械修饰候选物。这可能会延迟生物膜的形成并降低感染的风险。该涂层适用于多种基材（聚合物、非金属无机和金属），在 PBS 中浸泡 28 天后仍保持超疏水性能，表明它是一种很有前途的抗血栓和抗菌医疗器械修饰候选物。