Substrate-directed divergent synthesis of fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones,Chemical Communications

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Substrate-directed divergent synthesis of fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones
Chemical Communications ( IF 4.3 ) Pub Date : 2022-07-04 , DOI: 10.1039/d2cc02686d
Yang Zhao ₁ , Xinyue Niu ₁ , Hong Yang ₁ , Jing Yang ₁ , Zhizeng Wang ₂ , Qilin Wang ₁

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Herein, we report a substrate-directed diverse synthetic strategy toward two kinds of structurally intriguing fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones with enaminones. The subtle structural changes in enaminones lead to different reactivities. Cyclic enaminones produce indolo[2,3-b]indoles, whereas acyclic ones afford oxazolo[3,2-a]indoles.

中文翻译：

通过 Rh(II) 催化的双（重氮）二氢吲哚-2-酮的级联反应的底物定向发散合成稠合吲哚多环

在此，我们通过 Rh( II ) 催化的双 (diazo)indolin-2-ones 与烯胺酮的级联反应，报告了一种以底物为导向的多样化合成策略，可制备两种结构有趣的稠合吲哚多环化合物。烯胺酮的细微结构变化导致不同的反应性。环状烯胺酮产生吲哚[2,3- b ]吲哚，而无环烯胺酮产生恶唑并[3,2- a ]吲哚。

更新日期：2022-07-04

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