Synthesis of C-Aryl Glycosides via Ru-Catalyzed Remote C−H Glycosylation of 8-Aminoquinoline Amides,Advanced Synthesis & Catalysis

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Synthesis of C-Aryl Glycosides via Ru-Catalyzed Remote C−H Glycosylation of 8-Aminoquinoline Amides
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2022-07-03 , DOI: 10.1002/adsc.202200549
Wei-Yu Shi ₁ , Hu-Yi Li ₁ , Xue-Ya Gou ₁ , Yu-Yong Luan ₁ , Nian Zheng ₁ , Zhe Zhang ₁ , Zhi-Jie Niu ₁ , Xue-yuan Liu ₁ , Yong-Min Liang ₁

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C-Aryl glycoside is a class of structural motifs with important medicinal value. Herein, a remote C−H glycosylation strategy enabled by Ruthenium(II)-catalyzed with mostly α-stereoselectivity is described. This approach exhibits great functional group compatibility with various glycosides and arylamides. A series of experiments provided strong evidence for the free radical mechanism and reversible C−H activation process, and a possible mechanism was proposed.

中文翻译：

Ru催化8-氨基喹啉酰胺远程C-H糖基化合成C-芳基糖苷

C-芳基糖苷是一类具有重要药用价值的结构基序。本文描述了一种由钌 (II) 催化的远程 C-H 糖基化策略，主要具有 α-立体选择性。这种方法与各种糖苷和芳基酰胺表现出很好的官能团相容性。一系列实验为自由基机制和可逆C-H活化过程提供了有力证据，并提出了可能的机制。

更新日期：2022-07-03

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