The first total syntheses of natural phenanthrene alkaloids, namely, uvariopsamine (1), noruvariopsamine (2), 8-hydroxystephenanthrine (3), 8-methoxyuvariopsine (4), thalihazine (5), and secophoebine (6), have been realized. In addition, their in vitro antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum and in vitro cytotoxic activity against the human nasopharynx carcinoma (KB), small cell lung cancer (NCI-H187), and breast cancer (MCF7) human cancer cell lines were investigated. All the phenanthrene alkaloids showed significant antiplasmodial activity (IC₅₀ 1.07–7.41 µM), and most compounds displayed low to no toxicity against the three cancer cell lines tested. Particularly, 3 exhibited the best antimalarial activity with an IC₅₀ value of 1.07 µM, no toxicity to NCI-H187 (IC₅₀ > 50 µM), and low toxicity against KB (IC₅₀ 24.53 µM) and MCF7 (IC₅₀ 42.67 µM) cell lines.

已经实现了天然菲生物碱的第一次全合成，即葡萄毒胺（1）、去甲花毒胺（2）、8-羟基斯蒂芬碱（3）、8-甲氧基葡萄毒碱（4）、噻嗪（5）和环磷碱（6）。此外，它们对恶性疟原虫的多重耐药 K1 株的体外抗疟活性和对人鼻咽癌 (KB)、小细胞肺癌 (NCI-H187) 和乳腺癌 (MCF7) 人癌症的体外细胞毒活性细胞系进行了研究。所有菲生物碱均显示出显着的抗疟原虫活性（IC₅₀ 1.07–7.41 µM），大多数化合物对所测试的三种癌细胞系表现出低毒性甚至没有毒性。其中3种抗疟活性最好，IC ₅₀值为1.07 µM，对NCI-H187无毒性（IC ₅₀  > 50 µM），对KB（IC ₅₀ 24.53 µM）和MCF7（IC ₅₀ 42.67 µM）毒性低细胞系。