Herein, a facile and general electroreductive deuteration of unactivated alkyl halides (X = Cl, Br, I) or pseudo-halides (X = OMs) using D₂O as the economical deuterium source was reported. In addition to primary and secondary alkyl halides, sterically hindered tertiary chlorides also work very well, affording the target deuterodehalogenated products with excellent efficiency and deuterium incorporation. More than 60 examples are provided, including late-stage dehalogenative deuteration of natural products, pharmaceuticals, and their derivatives, all with excellent deuterium incorporation (up to 99% D), demonstrating the potential utility of the developed method in organic synthesis. Furthermore, the method does not require external catalysts and tolerates high current, showing possible use in industrial applications.

_{在此，报道了使用D 2} O作为经济的氘源对未活化的烷基卤化物(X = Cl、Br、I)或拟卤化物(X = OMs)进行简便且通用的电还原氘化。除了伯烷基卤和仲烷基卤之外，位阻叔氯化物也能很好地发挥作用，为目标氘代脱卤产物提供优异的效率和氘掺入。提供了 60 多个示例，包括天然产物、药物及其衍生物的后期脱卤氘化，所有样品均具有出色的氘掺入率（高达 99% D），展示了所开发方法在有机合成中的潜在用途。此外，该方法不需要外部催化剂并且可以承受高电流，显示出在工业应用中的潜在用途。