电子烟蒸气和低 THC 大麻烟雾中大麻二酚 (CBD) 向四氢大麻酚 (THC) 的相关热转化缺失,ChemRxiv

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电子烟蒸气和低 THC 大麻烟雾中大麻二酚 (CBD) 向四氢大麻酚 (THC) 的相关热转化缺失
ChemRxiv Pub Date : 2022-06-29 , DOI: 10.26434/chemrxiv-2022-spw0d-v2
Pascal Hindelang ₁ , Andreas Scharinger ₁ , Patricia Golombek ₁ , Miriam Laible ₂ , Sandra Tamosaite ₂ , Stephan G. Walch ₁ , Dirk W. Lachenmeier ₁

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简介：最近的研究声称，商业电子烟（电子烟）液体中的大麻二酚 (CBD) 可以转化为精神药物量的 Δ9-四氢大麻酚 (THC)。本研究旨在通过现实的电子烟装置来验证这一说法。此外，本研究还调查了在吸食富含 CBD 的大麻关节期间是否可能发生这种转变。方法：使用两种不同的电子烟模型蒸发两种不同的 CBD 液体，其中一种在极端能量设置（0.2 Ω 和 200 W）下运行。根据 ISO 4387:2019 使用旋转吸烟机收集六个 CBD 接头的烟雾。使用核磁共振 (NMR) 光谱法以及液相色谱串联质谱法 (LC-MS/MS) 进行分析。结果：对于浓缩的电子烟液体，没有观察到 THC 浓度的增加。对于 CBD 接头，无法证明 THC 的形成。回收的 THC 浓度介于吸烟前关节中最初含有的 THC 量的 1% 到 48% 之间。结论：使用消费者接触的现实条件，CBD 到 THC 的相关转化似乎没有发生。用于电子烟的 CBD 液体以及用于吸烟的低 THC 大麻的健康风险可以通过源材料中的浓度来评估，而无需考虑消费者在使用过程中精神药物的显着变化。结论：使用消费者接触的现实条件，CBD 到 THC 的相关转化似乎没有发生。用于电子烟的 CBD 液体以及用于吸烟的低 THC 大麻的健康风险可以通过源材料中的浓度来评估，而无需考虑消费者在使用过程中精神药物的显着变化。结论：使用消费者接触的现实条件，CBD 到 THC 的相关转化似乎没有发生。用于电子烟的 CBD 液体以及用于吸烟的低 THC 大麻的健康风险可以通过源材料中的浓度来评估，而无需考虑消费者在使用过程中精神药物的显着变化。

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Absence of Relevant Thermal Conversion of Cannabidiol (CBD) to Tetrahydrocannabinol (THC) in E-Cigarette Vapor and Low-THC Cannabis Smoke

Introduction: Recent research claimed that cannabidiol (CBD) in commercial electronic cigarette (e-cigarette) liquids can be converted into psychotropic amounts of ∆9-tetrahydrocannabinol (THC). This study aims to validate this claim by a realistic e-cigarette setup. Additionally, this study also investigates if such a conversion may occur during smoking of CBD-rich cannabis joints. Methods: Two different CBD-liquids were vaporized using two different e-cigarette models, one of which was operated at extreme energy settings (0.2 Ω and 200 W). The smoke of six CBD joints was collected using a rotary smoking machine according to ISO 4387:2019. Analyses were conducted using nuclear magnetic resonance (NMR) spectrometry as well as liquid chromatography tandem mass spectrometry (LC-MS/MS). Results: For the condensed e-cigarette liquids, no increase in THC concentration could be observed. For the CBD joints, no formation of THC was provable. The recovered THC concentrations were ranging between 1% and 48% of the THC amount initially contained in the joints before smoking. Conclusions: Using realistic conditions of consumer exposure, relevant conversion of CBD to THC appears not to be occurring. The health risk of CBD liquids for electronic cigarettes as well as low-THC cannabis intended for smoking can be assessed by the concentrations in the source material without need to consider significant changes in psychotropic compounds during use by consumers.

更新日期：2022-06-29

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