Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice,Clinical and Translational Medicine

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Phosphoproteome reveals molecular mechanisms of aberrant rhythm in neurotransmitter-mediated islet hormone secretion in diabetic mice
Clinical and Translational Medicine ( IF 7.919 ) Pub Date : 2022-06-27 , DOI: 10.1002/ctm2.890
Yunqiang He ₁ , Qi Fu ₁ , Min Sun ₁ , Yu Qian ₁ , Yucheng Liang ₁ , Jie Zhang ₁ , Rui Gao _{1,

2} , Hemin Jiang ₁ , Hao Dai ₁ , Yuwei Liu ₁ , Xinyu Xu ₁ , Heng Chen ₁ , Kuanfeng Xu ₁ , Tao Yang ₁

Affiliation

Acetylcholine (ACh) and norepinephrine (NE) are representative neurotransmitters of parasympathetic and sympathetic nerves, respectively, that antagonize each other to coregulate internal body functions. This also includes the control of different kinds of hormone secretion from pancreatic islets. However, the molecular mechanisms have not been fully elucidated, and whether innervation in islets is abnormal in diabetes mellitus also remains unclear.

中文翻译：

磷酸蛋白质组揭示糖尿病小鼠神经递质介导的胰岛激素分泌异常节律的分子机制

乙酰胆碱 (ACh) 和去甲肾上腺素 (NE) 分别是副交感神经和交感神经的代表性神经递质，它们相互拮抗以共同调节体内功能。这还包括控制胰岛不同种类的激素分泌。然而，分子机制尚未完全阐明，糖尿病患者胰岛神经支配是否异常也尚不清楚。

更新日期：2022-06-29

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