Lysosome-Targeting Polysiloxane Fluorescent Probe for Continuous Detection of Fe3+, Cu2+, and H2O2,Macromolecular Chemistry and Physics

当前位置： X-MOL 学术 › Macromol. Chem. Phys. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lysosome-Targeting Polysiloxane Fluorescent Probe for Continuous Detection of Fe3+, Cu2+, and H2O2
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2022-06-25 , DOI: 10.1002/macp.202200128
Yafang Zhang ₁ , Guowei Ding ₁ , Fengqing Gai ₁ , Kun Zhang ₁ , Zhiming Gou ₁ , Yujing Zuo ₁

Affiliation

In this study, a simple and nontoxic polysiloxane fluorescent probe (P1) is synthesized to detect iron ions, copper ions, and hydrogen peroxide (H₂O₂). Interestingly, both Fe³⁺ and Cu²⁺ can gradually quench the fluorescence intensity of the probe, and H₂O₂ can reproduce the probe quenched by Cu²⁺ instead of Fe³⁺. The probe shows high selectivity and photostability, and the fluorescence intensity can keep at 95.77% after irradiation at 260 nm for 40 min. In addition, P1 can stably locate lysosome. With excellent property, the probe as lysosome tracker has broad application prospects in detection and biological imaging.

中文翻译：

用于连续检测 Fe3+、Cu2+ 和 H2O2 的溶酶体靶向聚硅氧烷荧光探针

本研究合成了一种简单无毒的聚硅氧烷荧光探针（P1），用于检测铁离子、铜离子和过氧化氢（H ₂ O ₂）。有趣的是，Fe ³⁺和Cu ²⁺都可以逐渐淬灭探针的荧光强度，而H ₂ O ₂可以再现被Cu ²⁺而不是Fe ³⁺淬灭的探针。该探针具有较高的选择性和光稳定性，在260 nm照射40 min后荧光强度可保持在95.77%。此外，P1 可以稳定地定位溶酶体。该探针作为溶酶体跟踪器具有优异的性能，在检测和生物成像方面具有广阔的应用前景。

更新日期：2022-06-25

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南