A catalytic asymmetric vinylogous Mannich/annulation/acylation reaction of 2-ethylidene 1,3-indandiones with isatin N-Boc ketimines has been developed, which furnished a series of chiral spiro-oxindole piperidine derivatives with polyaromatic scaffolds in 30–67% yield and 93–98% ee. The DFT computational calculation is used to probe and explain the origin of the enantioselectivity and observed formation of O-acetylated products.

中文翻译：

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2-亚乙基 1,3-茚满二酮和靛红 N-Boc 酮亚胺的不对称序列乙烯基曼尼希/环化/酰化过程：获得手性螺氧吲哚哌啶衍生物

开发了 2-亚乙基 1,3-茚满二酮与靛红N -Boc 酮亚胺的催化不对称插烯曼尼希/环化/酰化反应，以 30-67% 的产率和93–98% EE。DFT计算计算用于探测和解释对映选择性的起源和观察到的O-乙酰化产物的形成。