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Convection-enhanced delivery with controlled catheter movement: A parametric finite element analysis
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2022-06-28 , DOI: 10.1002/cnm.3635 Jason N Mehta 1 , Manuel K Rausch 2 , Christopher G Rylander 1
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2022-06-28 , DOI: 10.1002/cnm.3635 Jason N Mehta 1 , Manuel K Rausch 2 , Christopher G Rylander 1
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Convection-enhanced delivery (CED) is an investigational method for delivering therapeutics directly to the brain for the treatment of glioblastoma. However, it has not become a common clinical therapy due to an inability of CED treatments to deliver therapeutics in a large enough tissue volume to fully saturate the target region. We have recently shown that the combination of controlled catheter movement and constant pressure infusions can be used to significantly increase volume dispersed (Vd) in an agarose gel brain tissue phantom. In the present study, we develop a computational model to predict Vd achieved by various retraction rates with both constant pressure and constant flow rate infusions. An increase in Vd is achieved with any movement rate, but increase in Vd between successive movement rates drops off at rates above 0.3–0.35 mm/min. Finally, we found that infusions with retraction result in a more even distribution in concentration level compared to the stationary catheter, suggesting a potential increased ability for moving catheters to have a therapeutic impact regardless of the required therapeutic concentration level.
中文翻译：
受控导管运动的对流增强输送：参数化有限元分析
对流增强递送（CED）是一种直接向大脑递送治疗药物以治疗胶质母细胞瘤的研究方法。然而，由于 CED 治疗无法在足够大的组织体积中提供治疗以完全饱和目标区域，因此它尚未成为常见的临床疗法。我们最近表明，受控导管运动和恒压输注的结合可用于显着增加琼脂糖凝胶脑组织模型中分散的体积（ V d ）。在本研究中，我们开发了一个计算模型来预测恒定压力和恒定流量输注的不同回缩率所实现的V d 。任何运动速率均可实现V d的增加，但连续运动速率之间的V d增加在速率高于 0.3-0.35 mm/min 时会下降。最后，我们发现与固定导管相比，回缩输注导致浓度水平分布更均匀，这表明无论所需的治疗浓度水平如何，移动导管产生治疗影响的能力都有可能增加。
更新日期：2022-06-28
中文翻译：
受控导管运动的对流增强输送：参数化有限元分析
对流增强递送（CED）是一种直接向大脑递送治疗药物以治疗胶质母细胞瘤的研究方法。然而，由于 CED 治疗无法在足够大的组织体积中提供治疗以完全饱和目标区域，因此它尚未成为常见的临床疗法。我们最近表明，受控导管运动和恒压输注的结合可用于显着增加琼脂糖凝胶脑组织模型中分散的体积（ V d ）。在本研究中，我们开发了一个计算模型来预测恒定压力和恒定流量输注的不同回缩率所实现的V d 。任何运动速率均可实现V d的增加，但连续运动速率之间的V d增加在速率高于 0.3-0.35 mm/min 时会下降。最后，我们发现与固定导管相比，回缩输注导致浓度水平分布更均匀，这表明无论所需的治疗浓度水平如何，移动导管产生治疗影响的能力都有可能增加。
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