The solubility of 2-amino-3-chloropyrazine (ACPY) in some binary cosolvent mixtures of (methanol, isopropyl alcohol, ethylene glycol (EG), N,N-dimethylformamide (DMF)) plus water and the experimental solubility of 2-amino-3,5-dibromopyrazine (ADPY) in (ethanol + water), (isopropyl alcohol + water), (EG + water), and (PG + water) were all determined by the isothermal saturation method from 278.15 K to 323.15 K at 101.2 kPa. The trend of the system temperature and the change of the solvent partner are both factors that affect the dissolution. As the temperature goes higher, the amount of dissolution follows, but the higher is the water content of the solvent, the less solute will be dissolved. The combination of DMF and water is best for the dissolution of ACPY, and the addition of ethanol to water shows an advantage of dissolving ADPY over other combinations. The experimentally obtained dissolution data were then calculated by using three models for the two miscible solvent systems. For ADPY, RAD and RMSD maximums were 2.63 × 10^–2 and 2.10 × 10^–5. For ACPY, RAD and RMSD were no greater than 6.55 × 10^–2 and 6.83 × 10^–4.

中文翻译：

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2-Amino-3-chloropyrazine 和 2-Amino-3,5-dibromopyrazine 在一系列混合溶剂系统中 T = (278.15 to 323.15) K 的溶解度测量和相关性

2-氨基-3-氯吡嗪 (ACPY) 在 (甲醇、异丙醇、乙二醇 (EG)、N,N的一些二元共溶剂混合物中的溶解度-二甲基甲酰胺 (DMF)) 加水和 2-氨基-3,5-二溴吡嗪 (ADPY) 在 (乙醇 + 水)、(异丙醇 + 水)、(EG + 水) 和 (PG + 水) 中的实验溶解度) 均通过等温饱和法在 101.2 kPa 下从 278.15 K 到 323.15 K 测定。系统温度的变化趋势和溶剂伙伴的变化都是影响溶出度的因素。随着温度升高，溶解量随之增加，但溶剂的含水量越高，溶解的溶质就越少。DMF 和水的组合最有利于 ACPY 的溶解，向水中添加乙醇显示出溶解 ADPY 优于其他组合的优势。然后通过使用两种混溶溶剂系统的三个模型计算实验获得的溶解数据。^–2和 2.10 × 10 ^–5。对于 ACPY，RAD 和 RMSD 不大于 6.55 × 10 ^–2和 6.83 × 10 ^–4。