The anabolic steroid 5α-androst-2-en-17-one (2EN) is sold as a prohormone and has been investigated regarding its potential as a steroidal aromatase inhibitor. The administration of 2EN was detected in a doping control sample in 2015, and investigations into its metabolism allowed for the identification and characterization of three urinary metabolites. Unfortunately, the utility of the main metabolite 2β,3α-dihydroxy-5α-androstan-17-one for doping control purposes was hampered under routine doping control conditions due to chromatographic issues, thus warranting further studies on the metabolism of the prohibited substance.

中文翻译：

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5α-androst-2-en-17-one体内代谢的研究

合成代谢类固醇 5α-androst-2-en-17-one (2EN) 作为激素原出售，并已对其作为类固醇芳香酶抑制剂的潜力进行了研究。2015 年在兴奋剂对照样本中检测到 2EN 的给药，对其代谢的调查允许鉴定和表征三种尿液代谢物。不幸的是，由于色谱问题，在常规兴奋剂控制条件下，主要代谢物 2β,3α-dihydroxy-5α-androstan-17-one 用于兴奋剂控制目的的效用受到阻碍，因此需要进一步研究禁用物质的代谢。