The synthesis of multi-substituted 1-aminoisoquinolines from aminopyridine pivalamides with alkynes by Rh(III)-catalyzed CH activation coupling has been investigated. This method proved to be tolerant of synthetically versatile functional groups, and provided access to a few highly substituted isoquinoline derivatives with remarkable fluorescence properties in moderate yields.

中文翻译：

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通过 Rh(III) 催化的氨基吡啶新戊酰胺与内部炔烃的氧化环化有效获得多取代的 1-氨基异喹啉

研究了由氨基吡啶新戊酰胺与炔烃通过 Rh(III) 催化的 C H 活化偶联合成多取代的 1-氨基异喹啉。该方法被证明可以耐受合成的多功能官能团，并以中等产率提供了一些具有显着荧光特性的高度取代的异喹啉衍生物。