Engineered Hemostatic Biomaterials for Sealing Wounds,Chemical Reviews

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Engineered Hemostatic Biomaterials for Sealing Wounds
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-06-22 , DOI: 10.1021/acs.chemrev.1c01015
Hossein Montazerian _{1,

2,

3} , Elham Davoodi _{1,

2,

3,

4} , Avijit Baidya ₅ , Sevana Baghdasarian ₅ , Einollah Sarikhani ₁ , Claire Elsa Meyer ₆ , Reihaneh Haghniaz ₃ , Maryam Badv _{2,

6,

7} , Nasim Annabi _{1,

5} , Ali Khademhosseini ₃ , Paul S Weiss _{1,

2,

6,

8}

Affiliation

Hemostatic biomaterials show great promise in wound control for the treatment of uncontrolled bleeding associated with damaged tissues, traumatic wounds, and surgical incisions. A surge of interest has been directed at boosting hemostatic properties of bioactive materials via mechanisms triggering the coagulation cascade. A wide variety of biocompatible and biodegradable materials has been applied to the design of hemostatic platforms for rapid blood coagulation. Recent trends in the design of hemostatic agents emphasize chemical conjugation of charged moieties to biomacromolecules, physical incorporation of blood-coagulating agents in biomaterials systems, and superabsorbing materials in either dry (foams) or wet (hydrogel) states. In addition, tough bioadhesives are emerging for efficient and physical sealing of incisions. In this Review, we highlight the biomacromolecular design approaches adopted to develop hemostatic bioactive materials. We discuss the mechanistic pathways of hemostasis along with the current standard experimental procedures for characterization of the hemostasis efficacy. Finally, we discuss the potential for clinical translation of hemostatic technologies, future trends, and research opportunities for the development of next-generation surgical materials with hemostatic properties for wound management.

中文翻译：

用于封闭伤口的工程止血生物材料

止血生物材料在伤口控制方面显示出巨大的前景，可用于治疗与受损组织、创伤性伤口和手术切口相关的不受控制的出血。人们对通过以下方式提高生物活性材料的止血性能产生了浓厚的兴趣触发凝血级联的机制。多种生物相容性和生物可降解材料已被应用于设计用于快速凝血的止血平台。止血剂设计的最新趋势强调带电部分与生物大分子的化学共轭，生物材料系统中凝血剂的物理结合，以及干（泡沫）或湿（水凝胶）状态的超吸收材料。此外，用于有效和物理密封切口的坚韧生物粘合剂正在出现。在这篇综述中，我们重点介绍了用于开发止血生物活性材料的生物大分子设计方法。我们讨论了止血的机制途径以及目前用于表征止血功效的标准实验程序。最后，

更新日期：2022-06-22

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