Upconversion Luminescence-Boosted Escape of DNAzyme from Endosomes for Enhanced Gene-Silencing Efficacy,Angewandte Chemie International Edition

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Upconversion Luminescence-Boosted Escape of DNAzyme from Endosomes for Enhanced Gene-Silencing Efficacy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-22 , DOI: 10.1002/anie.202206485
Yaoxuan Chen _{1,

2} , Rupeng Zhao _{1,

2} , Lele Li _{1,

2} , Yuliang Zhao _{1,

2}

Affiliation

An upconversion luminescence-controlled strategy is reported for efficient delivery of therapeutic DNAzyme via NIR light-boosted endosomal escape. The system enables enhanced gene-silencing efficacy and combinational therapeutic outcome, thus providing a robust approach to overcome current limitations of DNAzyme delivery.

中文翻译：