In this study, ZrO₂, TiO₂, and Fe₃O₄ components were synthesized by co-precipitation, sol–gel, and co-precipitation methods, respectively. In addition, solid-state dispersion method was used for synthesizing of ZrO₂/TiO₂/Fe₃O₄ ternary nanocomposite. The ZrO₂/TiO₂/Fe₃O₄ nanocomposite was characterized by different techniques including XRD, EDX, SEM, BET, FTIR, XPS, EELS, and Photoluminescence (PL). The FTIR analysis of ZrO₂/TiO₂/Fe₃O₄ photocatalyst showed strong peaks in the range of 450 to 700 cm⁻¹, which represent stretching vibrations of Zr–O, Ti–O, and Fe–O. The results of FTIR and XRD, XPS analyses and PL spectra confirmed that the solid-state dispersion method produced ZrO₂/TiO₂/Fe₃O₄ nanocomposites. The EELS analysis confirmed the pure samples of Fe₃O₄, TiO₂ and ZrO₂. The EDAX analysis showed that the Zr:Ti:Fe atomic ratio was 0.42:2.08:1.00. The specific surface area, pores volume and average pores size of the photocatalyst were obtained 280 m²/g, 0.92 cm³/g, and 42 nm respectively. Furthermore, the performance of ZrO₂/TiO₂/Fe₃O₄ nanocomposite was evaluated for naproxen removal using the response surface method (RSM). The four parameters such as NPX concentration, time, pH and catalyst concentration was investigated. The point of zero charge of the photocatalyst was 6. The maximum and minimum degradation of naproxen using photocatalyst were 100% (under conditions: NPX concentration = 10 mg/L, time = 90 min, pH = 3 and catalyst concentration = 0.5 g/L) and 66.10% respectively. The stability experiment revealed that the ternary nanocatalyst demonstrates a relatively higher photocatalytic activity after 7 recycles.