As climate change proceeds, the management of the population of mosquitoes becomes more and more challenging. Insect adulticides and larvicides constitute significant control techniques, with the latter being considered the leading mosquito control method. However, the development of mosquito resistance development and the adverse side effects caused by the extensive use of synthetic insecticides have turned research towards the discovery of environmentally-friendly solutions. Plants and bacteria have historically proven to be a good source of insecticidally active compounds, which may possess novel modes of action to overcome current resistance mechanisms and could also possess favorable human and environmental safety profiles. A previous study demonstrated that the naturally occurring prenylated acyl phloroglucinol deoxycohumulone is a potent larvicidal agent against Culex pipiens. Herein the structural characteristics that improve it are explored by evaluating colupulone and novel geranylated analogues.

中文翻译：

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Colupulone、colupone 和新型脱氧香叶香叶基类似物作为杀幼虫剂对抗淡色库蚊

随着气候变化的发展，蚊子种群的管理变得越来越具有挑战性。杀虫剂和杀幼虫剂是重要的控制技术，后者被认为是主要的蚊子控制方法。然而，蚊子抗药性的发展和大量使用合成杀虫剂引起的不良副作用已将研究转向发现环境友好的解决方案。植物和细菌历来被证明是杀虫活性化合物的良好来源，它们可能具有克服当前抗性机制的新作用模式，还可能具有良好的人类和环境安全特征。淡色库蚊。本文通过评估 colupulone 和新的香叶基化类似物来探索改善它的结构特征。