Scutellaria genus, a member of the Lamiaceae family, distributed worldwide and known as skullcaps, contains a wide range of pharmacologically active constituents including flavonoids and diterpenes. There are different classes of diterpenes in the plant kingdom, of which many have medicinal applications. Scutellaria spp. contain neo-clerodane diterpenes, a large group of naturally occurring specialized metabolites found in both plant species and in organisms from other taxonomic groups, such as fungi, bacteria, and marine sponges. Although many phytochemical studies have been established reporting interesting specialized diterpene structures from Scutellaria spp., there has not been a comprehensive study reviewing these compounds. Hence, the present review reports on natural diterpenoids from the Scutellaria genus and their pharmacological activities. For this purpose, the scientific databases including Scopus, PubMed, and Google Scholar were searched using the keywords “Scutellaria” and “Diterpenes” or “Diterpenoids”. The literature review showed that up to now, more than 300 diterpenes have been isolated and reported from the Scutellaria genus, belonging to neo-clerodane scaffolds. Anticancer, antifeedant, phytotoxic, antimicrobial, and nitric oxide production inhibitory activities are the most reported properties for the diterpenoids from the Scutellaria genus. Diterpenes of Scutellaria spp. have therapeutic potentials to be used for the treatment of different diseases. Further phytochemical, pharmacological, and clinical studies are required in this regard.