Sensors for rapid and reliable detection of biomolecules are crucial for clinical medical diagnoses. Here, a rapid, ultra-sensitive, magnetic-assisted biosensor based on resonance Raman scattering at MoS₂@Fe₃O₄ composite nanoflowers is presented. Raman shifts and X-ray photoelectron spectra indicated that the composite was formed via Fe–S covalent bonds. Convenient magnetic separations could be performed because of the superparamagnetic Fe₃O₄ nanoparticles. MoS₂ E¹_2g and A_1g Raman peaks were used as probe signals for anti-interference immunoassays. The probe unit of the immunoassay also included goat anti-human IgG molecules that were used as the target analyte. Au substrates coupled with the goat anti-human IgG were used as capture units to form sandwich biosensors. Because of the magnetic enrichment, the detection limit was improved by three orders-of-magnitude and the detection time was reduced from 1.5 h to 1 min. Sandwich biosensors using MoS₂@Fe₃O₄ nanoflowers as Raman probes could be very promising sensors for proteins, antigens, and other immunogenic biopolymers, as well as for corpuscular viruses and cells.

用于快速、可靠地检测生物分子的传感器对于临床医学诊断至关重要。在此，提出了一种基于 MoS ₂ @Fe ₃ O ₄复合纳米花共振拉曼散射的快速、超灵敏、磁辅助生物传感器。拉曼位移和 X 射线光电子能谱表明该复合材料是通过 Fe-S 共价键形成的。由于超顺磁性 Fe ₃ O ₄纳米粒子，可以进行方便的磁分离。 MoS ₂ E ¹ _2g和A _1g拉曼峰用作抗干扰免疫测定的探针信号。免疫测定的探针单元还包括用作目标分析物的山羊抗人 IgG 分子。 Au 底物与山羊抗人 IgG 结合用作捕获单元，形成夹心生物传感器。由于磁富集，检测限提高了三个数量级，检测时间从1.5 h缩短至1 min。使用MoS ₂ @Fe ₃ O ₄纳米花作为拉曼探针的三明治生物传感器可能是非常有前途的蛋白质、抗原和其他免疫原性生物聚合物以及微粒病毒和细胞的传感器。