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金黄色葡萄球菌对宿主的粘附
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2022-06-15 , DOI: 10.1111/nyas.14807 Kirsten A Berry 1 , Mackenzie T A Verhoef 1 , Allison C Leonard 1 , Georgina Cox 1
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2022-06-15 , DOI: 10.1111/nyas.14807 Kirsten A Berry 1 , Mackenzie T A Verhoef 1 , Allison C Leonard 1 , Georgina Cox 1
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金黄色葡萄球菌是一种能够定植和感染人体大部分组织的病原菌，导致多种不同的临床结果。金黄色葡萄球菌对宿主的粘附对于宿主定植和感染的建立都是至关重要的。病原体成功的基础是复杂多样的粘附素库。在这篇综述中，我们讨论了不同类别的粘附素，包括考虑全身各种粘附部位以及每种感染类型的临床结果。针对金黄色葡萄球菌的疗法的开发 host–pathogen interaction is a relatively understudied area. Due to the increasing global threat of antimicrobial resistance, it is crucial that innovative and alternative approaches are considered. Neutralizing virulence factors, through the development of antivirulence agents, could reduce bacterial pathogenicity and the ever-increasing burden of S. aureus infections. This review provides insight into potentially efficacious adhesion-associated targets for the development of novel decolonizing and antivirulence strategies.
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更新日期：2022-06-15
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