壳聚糖和壳寡糖：具有多种生物活性的有前途的非植物源性益生元,International Journal of Molecular Sciences

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壳聚糖和壳寡糖：具有多种生物活性的有前途的非植物源性益生元
International Journal of Molecular Sciences ( IF 4.9 ) Pub Date : 2022-06-17 , DOI: 10.3390/ijms23126761
Zhiwei Guan _{1,

2} , Qiang Feng _{1,

3}

Affiliation

可生物降解的几丁质是第二丰富的天然多糖，广泛存在于蟹、虾、昆虫的外骨骼和真菌的细胞壁中。壳聚糖和壳寡糖（COS，也称为壳寡糖）是甲壳素最重要的两种脱乙酰衍生物。与甲壳素相比，壳聚糖和COS不仅具有更令人满意的理化性质，而且还表现出额外的生物活性，使其在食品、医药、农业等领域得到广泛应用。此外，由于其显着改善肠道微生物群的能力，壳聚糖和 COS 被认为是潜在的益生元。在这里，我们介绍了壳聚糖和COS的生产、理化性质、应用和药代动力学特征。此外，我们总结了关于它们的抗氧化、抗炎和抗菌活性的最新研究。重点综述了壳聚糖和COS益生元功能的研究进展。我们创造性地分析和讨论了壳聚糖和COS的这些活性及其理化性质的机制和相关性。我们的工作丰富了人们对这些非植物来源的益生元的理解。在此综述的基础上，探讨壳聚糖和COS的未来研究方向。总体而言，优化甲壳素衍生物的生产技术，丰富对其生物学功能的认识，将更能揭示其改善人类健康的能力。重点综述了壳聚糖和COS益生元功能的研究进展。我们创造性地分析和讨论了壳聚糖和COS的这些活性及其理化性质的机制和相关性。我们的工作丰富了人们对这些非植物来源的益生元的理解。在此综述的基础上，探讨壳聚糖和COS的未来研究方向。总体而言，优化甲壳素衍生物的生产技术，丰富对其生物学功能的认识，将更能揭示其改善人类健康的能力。重点综述了壳聚糖和COS益生元功能的研究进展。我们创造性地分析和讨论了壳聚糖和COS的这些活性及其理化性质的机制和相关性。我们的工作丰富了人们对这些非植物来源的益生元的理解。在此综述的基础上，探讨壳聚糖和COS的未来研究方向。总体而言，优化甲壳素衍生物的生产技术，丰富对其生物学功能的认识，将更能揭示其改善人类健康的能力。在此综述的基础上，探讨壳聚糖和COS的未来研究方向。总体而言，优化甲壳素衍生物的生产技术，丰富对其生物学功能的认识，将更能揭示其改善人类健康的能力。在此综述的基础上，探讨壳聚糖和COS的未来研究方向。总体而言，优化甲壳素衍生物的生产技术，丰富对其生物学功能的认识，将更能揭示其改善人类健康的能力。

"点击查看英文标题和摘要"

Chitosan and Chitooligosaccharide: The Promising Non-Plant-Derived Prebiotics with Multiple Biological Activities

Biodegradable chitin is the second-most abundant natural polysaccharide, widely existing in the exoskeletons of crabs, shrimps, insects, and the cell walls of fungi. Chitosan and chitooligosaccharide (COS, also named chitosan oligosaccharide) are the two most important deacetylated derivatives of chitin. Compared with chitin, chitosan and COS not only have more satisfactory physicochemical properties but also exhibit additional biological activities, which cause them to be widely applied in the fields of food, medicine, and agriculture. Additionally, due to their significant ability to improve gut microbiota, chitosan and COS are deemed prospective prebiotics. Here, we introduced the production, physicochemical properties, applications, and pharmacokinetic characteristics of chitosan and COS. Furthermore, we summarized the latest research on their antioxidant, anti-inflammatory, and antimicrobial activities. Research progress on the prebiotic functions of chitosan and COS is particularly reviewed. We creatively analyzed and discussed the mechanisms and correlations underlying these activities of chitosan and COS and their physicochemical properties. Our work enriched people’s understanding of these non-plant-derived prebiotics. Based on this review, the future directions of research on chitosan and COS are explored. Collectively, optimizing the production technology of chitin derivatives and enriching understanding of their biological functions will shed more light on their capability to improve human health.

更新日期：2022-06-18

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