Copper-Catalyzed Cascade Syntheses of 2H-benzo[b][1,4]thiazin-3(4H)-ones and Quinoxalin-2(1H)-ones through Capturing S and N Atom Respectively from AcSH and TsNH2,The Journal of Organic Chemistry

当前位置： X-MOL 学术 › J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper-Catalyzed Cascade Syntheses of 2H-benzo[b][1,4]thiazin-3(4H)-ones and Quinoxalin-2(1H)-ones through Capturing S and N Atom Respectively from AcSH and TsNH2
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2010-07-28 00:00:00 , DOI: 10.1021/jo101253a
Dingben Chen _{1,

2} , Zhi-Jing Wang ₁ , Weiliang Bao ₁

Affiliation

A copper-catalyzed cascade method has been developed to synthesize the 2H-benzo[b][1,4]thiazin-3(4H)-ones from 2-halo-N-(2-halophenyl)-acetamides 1 and AcSH via the S_N2/deacetylation/coupling process, and to synthesize the quinoxalin-2(1H)-ones from 1 and TsNH₂ via the S_N2/coupling/desulfonation process. The target products were obtained with diversity at three positions on their scaffolds.

中文翻译：

铜催化级联反应分别从AcSH和TsNH _2中捕获S和N原子，合成2 H-苯并[ b ] [1,4]噻嗪3（4 H）-酮和喹喔啉2（1 H）-酮。

开发了一种铜催化的级联方法，由2-卤代-N-（2-卤代苯基）-乙酰胺1和AcSH合成2 H-苯并[ b ] [1,4]噻嗪-3（4 H）-酮。通过S _ñ 2 /脱乙酰化/连结处理，并且以合成喹喔啉-2（1 ħ从） -酮1和TsNH ₂通过S _ñ 2 /联接/脱磺过程。获得目标产物，在其支架上的三个位置具有多样性。

更新日期：2010-07-28

点击分享查看原文

点击收藏

阅读更多本刊新发论文