当前位置：
X-MOL 学术
›
Appl. Organomet. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Synthesis, characterization, and α-glucosidase, cholinesterases, and tyrosinase inhibitory effects of axial substituted silicon and peripheral tetra-substituted copper (II), manganese (III) phthalocyanines
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2022-06-14 , DOI: 10.1002/aoc.6781 Berivan Arin Öztürmen 1 , Burak Barut 2 , Zekeriya Biyiklioglu 1
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2022-06-14 , DOI: 10.1002/aoc.6781 Berivan Arin Öztürmen 1 , Burak Barut 2 , Zekeriya Biyiklioglu 1
Affiliation
|
In this paper, we have synthesized axially di-(3,3-diphenylpropoxy) substituted silicon (DFP-Si) and peripherally tetra-(3,3-diphenylpropoxy) substituted copper (II), manganese (III) phthalocyanines (DFP-Cu, DFP-Mn). Then, the α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory effects of DFP-Si, DFP-Cu, and DFP-Mn were examined using spectrophotometric methods. DFP-Mn had the highest inhibitor effect on cholinesterases, tyrosinase, and α-glucosidase in a concentration-dependent manner. DFP-Mn inhibited α-glucosidase with IC50 value of 17.80 μM. Also, DFP-Mn also showed higher α-glucosidase inhibitory actions that acarbose used as a positive control. The inhibition percentages in the presence of DFP-Mn were 30.64 ± 2.24%, 51.96 ± 1.56%, and 72.96 ± 4.95%, respectively at 20, 40, and 100 μM on AChE. In the presence of DFP-Mn at 100 μM, the inhibition percentages were calculated as 52.18 ± 2.22% against tyrosinase. These results showed that the compound has potential to treat Diabetes mellitus but further studies are needed to confirm the antidiabetic effect of the compound.
中文翻译：
轴向取代硅和外围四取代铜 (II)、锰 (III) 酞菁的合成、表征和 α-葡萄糖苷酶、胆碱酯酶和酪氨酸酶抑制作用
在本文中，我们合成了轴向二（3,3-二苯基丙氧基）取代硅（DFP-Si）和外围四（3,3-二苯基丙氧基）取代铜（II）、锰（III）酞菁（DFP-Cu , DFP-Mn )。然后，使用分光光度法检测了DFP-Si、DFP-Cu和DFP-Mn的α-葡萄糖苷酶、乙酰胆碱酯酶、丁酰胆碱酯酶和酪氨酸酶抑制作用。DFP-Mn以浓度依赖性方式对胆碱酯酶、酪氨酸酶和α-葡萄糖苷酶具有最高的抑制作用。DFP-Mn抑制 α-葡萄糖苷酶，IC 50值为 17.80 μM。此外，DFP-Mn还显示出比阿卡波糖用作阳性对照更高的α-葡萄糖苷酶抑制作用。DFP-Mn在 20、40 和 100 μM 对 AChE的抑制百分比分别为 30.64 ± 2.24%、51.96 ± 1.56% 和 72.96 ± 4.95%。在 100 μM 的DFP-Mn存在下，对酪氨酸酶的抑制百分比计算为 52.18 ± 2.22%。这些结果表明该化合物具有治疗糖尿病的潜力，但需要进一步的研究来证实该化合物的抗糖尿病作用。
更新日期：2022-06-14
中文翻译：
轴向取代硅和外围四取代铜 (II)、锰 (III) 酞菁的合成、表征和 α-葡萄糖苷酶、胆碱酯酶和酪氨酸酶抑制作用
在本文中，我们合成了轴向二（3,3-二苯基丙氧基）取代硅（DFP-Si）和外围四（3,3-二苯基丙氧基）取代铜（II）、锰（III）酞菁（DFP-Cu , DFP-Mn )。然后，使用分光光度法检测了DFP-Si、DFP-Cu和DFP-Mn的α-葡萄糖苷酶、乙酰胆碱酯酶、丁酰胆碱酯酶和酪氨酸酶抑制作用。DFP-Mn以浓度依赖性方式对胆碱酯酶、酪氨酸酶和α-葡萄糖苷酶具有最高的抑制作用。DFP-Mn抑制 α-葡萄糖苷酶，IC 50值为 17.80 μM。此外，DFP-Mn还显示出比阿卡波糖用作阳性对照更高的α-葡萄糖苷酶抑制作用。DFP-Mn在 20、40 和 100 μM 对 AChE的抑制百分比分别为 30.64 ± 2.24%、51.96 ± 1.56% 和 72.96 ± 4.95%。在 100 μM 的DFP-Mn存在下，对酪氨酸酶的抑制百分比计算为 52.18 ± 2.22%。这些结果表明该化合物具有治疗糖尿病的潜力，但需要进一步的研究来证实该化合物的抗糖尿病作用。
京公网安备 11010802027423号