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Reactions of N-Benzyl- and N-(2-Phenylethyl)maleimides with Secondary Amines
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2022-06-14 , DOI: 10.1134/s1070363222050012 O. A. Kolyamshin , Yu. N. Mitrasov , V. A. Danilov , A. A. Avruyskaya , Yu. Yu. Pylchikova
中文翻译:
N-苄基和 N-(2-苯乙基)马来酰亚胺与仲胺的反应
更新日期:2022-06-15
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2022-06-14 , DOI: 10.1134/s1070363222050012 O. A. Kolyamshin , Yu. N. Mitrasov , V. A. Danilov , A. A. Avruyskaya , Yu. Yu. Pylchikova
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Abstract
It was found that the reactions of N-benzylmaleimide with secondary amines proceed at the double C=C bond and lead to the formation of 3-N,N-R2-aminosubstituted succinimides. In the case of N-phenethylmaleimide, the nucleophilic addition of secondary amines is accompanied by an amidation reaction, which proceeds with ring opening and leads to the formation of unsymmetrical maleic acid diamides.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
N-苄基和 N-(2-苯乙基)马来酰亚胺与仲胺的反应
摘要
发现N-苄基马来酰亚胺与仲胺的反应在C=C双键处进行并导致形成3 - N , N -R 2 -氨基取代的琥珀酰亚胺。在N-苯乙基马来酰亚胺的情况下,仲胺的亲核加成伴随着酰胺化反应,该反应进行开环并导致不对称马来酸二酰胺的形成。