Abstract

It was found that the reactions of N-benzylmaleimide with secondary amines proceed at the double C=C bond and lead to the formation of 3-N,N-R₂-aminosubstituted succinimides. In the case of N-phenethylmaleimide, the nucleophilic addition of secondary amines is accompanied by an amidation reaction, which proceeds with ring opening and leads to the formation of unsymmetrical maleic acid diamides.

中文翻译：

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N-苄基和 N-(2-苯乙基)马来酰亚胺与仲胺的反应

摘要

发现N-苄基马来酰亚胺与仲胺的反应在C=C双键处进行并导致形成3 - N , N -R ₂ -氨基取代的琥珀酰亚胺。在N-苯乙基马来酰亚胺的情况下，仲胺的亲核加成伴随着酰胺化反应，该反应进行开环并导致不对称马来酸二酰胺的形成。