Abstract

A new series of thienopyridine derivatives, namely N-(thieno[2,3-b]pyridin-3-yl)aminoalcohols, was obtained by a cascade deacylation/alkylation reaction of 3-aminothieno[2,3-b]pyridine ketones. An alternative approach to the synthesis of these compounds by alkylation of 3-aminothienopyridines unsubstituted at position 2 with diols was proposed.

中文翻译：

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3-氨基-2-苯甲酰基噻吩并[2,3-b]吡啶的级联转化

摘要

通过3-氨基噻吩并[2,3- b ]吡啶酮的级联脱酰/烷基化反应，得到了一系列新的噻吩并吡啶衍生物，即N- (噻吩并[2,3 - b ]吡啶-3-基)氨基醇。提出了通过用二醇烷基化 2 位未取代的 3-氨基噻吩并吡啶来合成这些化合物的替代方法。