Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion,ACS Applied Nano Materials

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Au–Cu Bimetallic Nanostructures for Photothermal Antibacterial and Wound Healing Promotion
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-06-14 , DOI: 10.1021/acsanm.2c02152
Qiuxian Song _{1,

2} , Yihan Liu _{1,

2} , Pan Zhang _{1,

2} , Wenli Feng _{1,

2} , Shaoze Shi _{1,

2} , Ninglin Zhou _{1,

2,

3} , Xiaohong Chu _{1,

2} , Jian Shen _{1,

2,

4}

Affiliation

The spread of drug-resistant bacterial infections can lead to serious infectious diseases and pose a significant threat to public health security. Metallic-nano-antibacterial materials are gradually becoming a hot spot for antimicrobial biomaterials research with the advantages of long service life and fast effective bactericidal speed. Considering the construction of a safe and efficient photothermal therapy (PTT) antibacterial platform as a promising strategy for the treatment of bacterial infections, a near-infrared (NIR) bimetallic antibacterial nanoparticle, adenosine 5′-triphosphate (ATP)@Au-Cu nanoparticle (NP), with excellent photothermal conversion efficiency (59.3%) was prepared in this paper; ATP@Au-CuNPs with their multiarm shaped structure and NIR photothermal effect could significantly inhibit the growth of bacteria at the low concentrations. In addition, the cytotoxicity and hemolysis rate of the ATP-coated nanoparticles were reduced considerably, and they also exhibited antibacterial and wound healing-promoting effects in mice wound infection models. On this basis, this paper focuses on the preparation and properties of ATP@Au-CuNPs and explores their biological application in antibacterial therapy.

中文翻译：

Au-Cu双金属纳米结构用于光热抗菌和促进伤口愈合

耐药细菌感染的传播可导致严重的传染病，并对公共卫生安全构成重大威胁。金属纳米抗菌材料具有使用寿命长、有效杀菌速度快等优点，正逐渐成为抗菌生物材料研究的热点。考虑到构建安全高效的光热疗法 (PTT) 抗菌平台作为治疗细菌感染的一种有前景的策略，一种近红外 (NIR) 双金属抗菌纳米颗粒，腺苷 5'-三磷酸 (ATP)@Au-Cu 纳米颗粒本文制备了具有优异光热转换效率（59.3%）的（NP）；ATP@Au-CuNPs 具有多臂状结构和近红外光热效应，可在低浓度下显着抑制细菌的生长。此外，ATP 包覆的纳米颗粒的细胞毒性和溶血率显着降低，在小鼠伤口感染模型中也表现出抗菌和促进伤口愈合的作用。在此基础上，本文重点研究了ATP@Au-CuNPs的制备和性质，并探讨了其在抗菌治疗中的生物学应用。

更新日期：2022-06-14

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