Discovery of a Potent and Selective Degrader for USP7,Angewandte Chemie International Edition

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Discovery of a Potent and Selective Degrader for USP7
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2022-06-12 , DOI: 10.1002/anie.202204395
Yuan Pei _{1,

2} , Jingfeng Fu _{1,

2} , Yunkai Shi _{1,

3} , Mengmeng Zhang ₁ , Guanghao Luo _{1,

2,

3} , Xiaomin Luo _{1,

4} , Ning Song _{1,

2} , Tian Mi _{1,

2} , Yaxi Yang _{1,

2,

3} , Jia Li _{1,

2,

3,

4,

5} , Yubo Zhou _{1,

2,

3,

4,

5} , Bing Zhou _{1,

2,

3}

Affiliation

A first-in-class selective USP7 degrader U7D-1 was developed, inducing potent USP7 degradation in different kinds of cell lines. Importantly, this degrader showed notable anti-proliferative activities in mutant p53 cancer cells, with USP7 inhibitor having no activity.

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