Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines,Organic Letters

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Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines
Organic Letters ( IF 4.9 ) Pub Date : 2015-06-03 00:00:00 , DOI: 10.1021/acs.orglett.5b01057
Ying Chen ₁ , Jinkun Huang ₁ , Tsang-Lin Hwang ₁ , Maosheng J. Chen ₁ , Jason S. Tedrow ₁ , Robert P. Farrell ₁ , Matthew M. Bio ₁ , Sheng Cui ₁

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A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.

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