A [3 ​+ ​2] cyclization reaction of acylacetonitriles and hydroxyacetone was developed by using Sc(OTf)₃ as a catalyst to synthesize some furan derivatives. Bifunctional C2-based acetals, such as α-bromoacetaldehyde acetal, 1,4-dithiane-2,5-diol and glycolaldehyde diethyl acetal, also reacted readily as alternative counterpart reagents to acylacetonitriles. The established reactions can be used to synthesize a well-known fungicide, fenfuram. Antifungal activity investigation against four common plant funguses indicated that some of the obtained furan products furnish general and high biological activities.

中文翻译：

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Sc(OTf)3 催化酰基乙腈和可再生丙酮醇合成多取代呋喃

以Sc(OTf) ₃为催化剂，发展了酰基乙腈和羟基丙酮的[3 + 2]环化反应，合成了一些呋喃衍生物。基于双功能 C2 的缩醛，例如α-溴乙醛缩醛、1,4-二噻烷-2,5-二醇和乙醇醛二乙缩醛，也很容易作为乙酰乙腈的替代对应试剂进行反应。已建立的反应可用于合成众所周知的杀菌剂芬弗兰。对四种常见植物真菌的抗真菌活性研究表明，部分获得的呋喃产物具有一般和较高的生物活性。