一种基于丝素蛋白的机械自适应水凝胶神经接口，用于高效的神经活动记录,Materials Horizons

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一种基于丝素蛋白的机械自适应水凝胶神经接口，用于高效的神经活动记录
Materials Horizons ( IF 12.2 ) Pub Date : 2022-06-08 , DOI: 10.1039/d2mh00533f
Jie Ding ₁ , Zhihong Chen ₁ , Xiaoyin Liu ₂ , Yuan Tian ₁ , Ji Jiang ₁ , Zi Qiao ₁ , Yusheng Zhang ₁ , Zhanwen Xiao ₁ , Dan Wei ₁ , Jing Sun ₁ , Fang Luo ₃ , Liangxue Zhou ₂ , Hongsong Fan ₁

Affiliation

一种灵活的非瞬态电平台，可以实现来自活组织的双向神经通信，对于更好地理解基础神经科学和疾病或病症的非药物治疗，对神经科学具有重要意义。开发具有机械耦合和高效电交换的柔软、生物相容性和导电性神经接口是一种新趋势，但仍然是一个挑战。在这里，我们设计了一个多功能的神经电通信平台，其形式为机械兼容、导电和生物相容的水凝胶电极。从Bombyx Mori获得的丝素蛋白 (SF)茧与具有动态网络的醛-透明质酸（HA-CHO）复合，以延迟或中断β-折叠诱导的SF链硬化，从而制造出与生物组织机械匹配的水凝胶基质。此外，功能化碳纳米管（CNTs）的加入促进了相互作用和分散，并能够形成具有高电流渗透网络的水凝胶电极，从而有助于提高电导率、阻抗和电荷存储能力方面的电性能。这些进步允许在体内进行高效刺激和神经信号记录植入。总体而言，广泛的动物实验表明，该平台表现出最小的异物反应，因此表明它是一种有前途的电生理学接口，可用于神经科学的潜在应用。

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A mechanically adaptive hydrogel neural interface based on silk fibroin for high-efficiency neural activity recording

A flexible non-transient electrical platform that can realize bidirectional neural communication from living tissues is of great interest in neuroscience to better understand basic neuroscience and the nondrug therapy of diseases or disorders. The development of soft, biocompatible, and conductive neural interface with mechanical coupling and efficient electrical exchange is a new trend but remains a challenge. Herein, we designed a multifunctional neural electrical communication platform in the form of a mechanically compliant, electrically conductive, and biocompatible hydrogel electrode. Silk fibroin (SF) obtained from Bombyx Mori cocoons was compounded with aldehyde-hyaluronic acid (HA-CHO) with a dynamic network to delay or interrupt the β-sheet-induced hardening of SF chains, resulting in the fabrication of a hydrogel matrix that is mechanically matched to biological tissues. Moreover, the incorporation of functionalized carbon nanotubes (CNTs) facilitated interaction and dispersion and enabled the formation of a hydrogel electrode with a high-current percolation network, thus contributing toward improving the electrical properties in terms of conductivity, impedance, and charge storage capabilities. These advances allow high-efficiency stimulation and the recording of neural signals during in vivo implantation. Overall, a wide range of animal experiments demonstrate that the platform exhibits minimal foreign body responses, thus showing it to be a promising electrophysiology interface for potential applications in neuroscience.

更新日期：2022-06-08

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