Abstract:This review described the preparation of 2-chloroquinoline-3-carbaldehyde derivatives, through Vilsmeier-Haack formylation of N-arylacetamides and used them as a key intermediate for preparation of 2-(piperidin-1-yl) and/ or 2-(morpholin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2-(piperidin-1-yl) and/ or 2-(morpholin-1-yl) quinolines derivative were explained through the following chemical reactions: reaction with active methyl and/ or methylene component, Claisen-Schmidt condensation, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction, etc….

中文翻译：

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2-(Pipridin-1-yl) 和/或 2-(Morpholin-1-yl) 喹啉的化学（第二部分）：合成、反应性和生物活性。

摘要：本文介绍了通过 Vilsmeier-Haack 甲酰化 N-芳基乙酰胺制备 2-氯喹啉-3-甲醛衍生物，并将其作为制备 2-(哌啶-1-基)和/或 2- (morpholin-1-yl) quinoline-3-carbaldehydes。2-(哌啶-1-基)和/或2-(吗啉-1-基)喹啉衍生物的合成通过以下化学反应进行解释：与活性甲基和/或亚甲基组分的反应、克莱森-施密特缩合、一锅多组分反应 (MCR)、还原胺化、格氏反应等。