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Benzothiazole: Synthetic Strategies, Biological Potential, and Interactions with Targets
Mini-Reviews in Organic Chemistry ( IF 1.9 ) Pub Date : 2022-03-01 , DOI: 10.2174/1570193x18666210308145703
Chanchal Singh 1 , Rajnish Kumar 1 , Avijit Mazumder 1 , Salahuddin 1 , Ajay Kumar 1 , Rakesh Sahu 1 , Shivali Mishra 1 , Mohd. Mustqeem Abdullah 2
Affiliation  

:Benzothiazole is a heterocyclic compound that contains a benzene ring fused with a five-member 1,3-thiazole ring. Several types of research have established its potential as an antimicrobial agent, anticancer agent, anti-epileptic agent, antiviral agent, etc. Nowadays, various effective drugs utilize the hybridization of two or more pharmacophores in a single-molecule for synergizing its pharmacological action or to interact with more than one target or to reduce the side effects associated with it. In this article, various strategies for the synthesis of different pharmacologically active hybrid compounds containing benzothiazole with different substituents are highlighted. Apart from presenting the synthesis strategies, the article also highlights various pharmacological actions and molecular interactions with different biological molecules of the potential drugs containing benzothiazole.

中文翻译:

苯并噻唑:合成策略、生物潜力和与靶标的相互作用

: 苯并噻唑是一种杂环化合物,含有一个与五元 1,3-噻唑环稠合的苯环。几种类型的研究已经确定了它作为抗菌剂、抗癌剂、抗癫痫剂、抗病毒剂等的潜力。如今,各种有效的药物利用单分子中两种或多种药效团的杂交来协同其药理作用或与多个目标相互作用或减少与之相关的副作用。本文重点介绍了合成具有不同取代基的苯并噻唑的不同药理活性杂化化合物的各种策略。除了介绍合成策略外,
更新日期:2022-03-01
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