Abstract Ultraviolet rays – B (UVB) can be efficiently absorbed by the cellular molecules of skin inducing damage within skin cells and a major cause of melanoma cancer. In recent years, several studies have reported the adverse effects of traditionally used organic and inorganic material-based sunscreens and UVB blockers. In this study, bovine serum albumin (BSA) has been used as a precursor to synthesize temperature- and pressure-dependent phase transition from sol (globular aggregates) – gel (hydrogels) – sol (carbon quantum dots) using a single-step hydrothermal method with an objective to develop an efficient and effective UVB blocker. The synthesized hydrogels exhibit UV – attenuation, self-fluorescence, and high biocompatibility properties that make them a suitable candidate for UV-blocker or sunscreen material. The biological efficacy of the hydrogels was studied through cyto-toxicity studies. Also, UVB blocking efficiency of developed hydrogel in primary mice skin cell culture as well as in vivo in mice model was studied. In vivo study on mice further demonstrated prominent thickening of stratum corneum and epidermis with perivascular edema in the dermis after 5 days of UVB exposure. Hence, this suggesting that hydrogel could be a potential candidate for protecting the skin from UVB exposure and reducing the threat of skin cancer.

中文翻译：

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通过水热工艺调整牛血清白蛋白的自组装相以合成新型功能性水凝胶，用于保护皮肤免受 UVB

摘要 紫外线 – B (UVB) 可以被皮肤的细胞分子有效吸收，从而导致皮肤细胞内的损伤，是黑色素瘤的主要原因。近年来，一些研究报告了传统使用的有机和无机材料防晒霜和 UVB 阻断剂的不利影响。在这项研究中，牛血清白蛋白 (BSA) 已被用作前体，使用单步水热合成从溶胶（球状聚集体）-凝胶（水凝胶）-溶胶（碳量子点）的温度和压力依赖性相变方法的目的是开发一种高效和有效的 UVB 阻断剂。合成的水凝胶表现出紫外线衰减、自荧光和高生物相容性，使其成为紫外线阻断剂或防晒材料的合适候选者。通过细胞毒性研究研究了水凝胶的生物学功效。此外，还研究了开发的水凝胶在原代小鼠皮肤细胞培养以及小鼠体内模型中的 UVB 阻断效率。对小鼠的体内研究进一步表明，在 UVB 暴露 5 天后，角质层和表皮显着增厚，真皮血管周围水肿。因此，这表明水凝胶可能是保护皮肤免受 UVB 照射和减少皮肤癌威胁的潜在候选者。对小鼠的体内研究进一步表明，在 UVB 暴露 5 天后，角质层和表皮显着增厚，真皮血管周围水肿。因此，这表明水凝胶可能是保护皮肤免受 UVB 照射和减少皮肤癌威胁的潜在候选者。对小鼠的体内研究进一步表明，在 UVB 暴露 5 天后，角质层和表皮显着增厚，真皮血管周围水肿。因此，这表明水凝胶可能是保护皮肤免受 UVB 照射和减少皮肤癌威胁的潜在候选者。