Background:Condensed triazoles are a well-known class of heterocyclic compounds due to a wide range of biological activity. The study is dedicated to the evaluation of the antimicrobial potential of new functional derivatives of thiazolo[2,3-c][1,2,4]triazoles.Methods:Effective, easy-to-implement and low-cost routes to the production of title compounds via electrophilic intramolecular heterocyclization are reported. Bactericidal and fungicidal activities against Gram-positive and Gram-negative bacteria, and fungus were studied. The influence of functional groups on the biological activity of tested thiazolo[2,3-c][1,2,4]triazoles is discussed.Results:Microbiological evaluation shows that 6-[(trichlorotellanyl)methyl]-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-amine hydrogen chloride 2a and 3-(2-hydroxyphenyl)-6-[(trichloro-λ4-tellanyl)methyl]-5,6-dihydro-[1,3]thiazolo[2,3-c][1,2,4]triazole 2g have a high bactericidal activity and Cu (I) salts of 3-(2-hydroxyphenyl)-6-iodomethyl/6-methylidene-5,6-dihydro-[1,3]thiazolo-[2,3-c][1,2,4]triazoles 5a,c have a high fungicidal activity.Conclusion:it must be concluded that these products or their derivatives may be of practical benefit as bactericidal and fungicidal agents.

中文翻译：

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噻唑并[2,3-c][1,2,4]三唑的功能衍生物的合成及抗菌活性。

背景：缩合三唑是一类众所周知的杂环化合物，具有广泛的生物活性。该研究致力于评估噻唑并[2,3-c][1,2,4]三唑类新功能衍生物的抗菌潜力。方法：有效、易于实施和低成本的生产途径报道了通过亲电分子内杂环化的标题化合物。研究了对革兰氏阳性菌和革兰氏阴性菌以及真菌的杀菌和杀真菌活性。讨论了官能团对被测噻唑并[2,3-c][1,2,4]三唑类生物活性的影响。结果：微生物学评价表明，6-[(trichlorotellanyl)methyl]-[1,3]噻唑并[2,3-c][1,2,4]三唑-3-胺氯化氢2a和3-(2-羟基苯基)-6-[(三氯-λ4-碲基)甲基]-5，