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Stimuli-Responsive Hybrid Vesicle for Tumor Dual-Model NIR-II Photoacoustic and Fluorescence Imaging and Precise Radiotherapy
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2022-06-07 , DOI: 10.1002/adom.202200694 Ningning Lv 1 , Xuan Zhang 2 , Shuhan Wang 2 , Ying Wu 2 , Xiaoguang Ge 2 , Jibin Song 2 , Qingjie Ma 1, 3 , Shi Gao 1, 3
Advanced Optical Materials ( IF 8.0 ) Pub Date : 2022-06-07 , DOI: 10.1002/adom.202200694 Ningning Lv 1 , Xuan Zhang 2 , Shuhan Wang 2 , Ying Wu 2 , Xiaoguang Ge 2 , Jibin Song 2 , Qingjie Ma 1, 3 , Shi Gao 1, 3
Affiliation
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Bioimaging guided-radiotherapy is widely investigated as one of the mainstream cancer theranostic strategies for precision medicine. Nevertheless, background noise with “always-on” imaging signal and inadequate tumor enrichment restrict disease diagnosis and therapy. Here, a nanogapped gold nanoparticles (AuNNPs)–silver sulfide (Ag2S) vesicle (Ve) is designed as a “biological switch” through the self-assembly of pH-responsive polymer thiolated polystyrene-co-poly(4-vinylpyridine) grafted AuNNPs and Ag2S quantum dots (QDs). The AuNNPs–Ag2S Ve exhibits quenched NIR-II fluorescence (FL) and enhanced photoacoustic signals initially, which can be specifically activated by an acidic environment to release Ag2S QDs and “turn on” NIR-II FL signal in the second near-infrared (NIR-II, 950–1700 nm) window. Besides, the strategy of disease-located NIR-II imaging guided cancer therapy can remarkably enhance the therapeutic efficacy of radiotherapy, as well as minimize side effects. Such an intelligent nanoplatform with the ability of stimulus activated NIR-II imaging guided radiotherapy shows great promise to precision biomedicine in the future.
中文翻译：
用于肿瘤双模型 NIR-II 光声和荧光成像和精确放射治疗的刺激响应混合囊泡
生物成像引导放射治疗作为精准医学的主流癌症治疗策略之一被广泛研究。然而，具有“永远在线”成像信号的背景噪声和不充分的肿瘤富集限制了疾病的诊断和治疗。在这里，纳米间隙金纳米粒子（AuNNPs）-硫化银（Ag 2 S）囊泡（Ve）通过pH响应性聚合物硫醇化聚苯乙烯-共聚（4-乙烯基吡啶）的自组装被设计为“生物开关”接枝的AuNNPs和Ag 2 S量子点（QDs）。AuNNPs–Ag 2 S Ve 最初表现出猝灭的 NIR-II 荧光 (FL) 和增强的光声信号，可以被酸性环境特异性激活以释放 Ag 2S QD 和在第二个近红外（NIR-II，950–1700 nm）窗口中“打开”NIR-II FL 信号。此外，疾病定位的 NIR-II 成像引导癌症治疗策略可以显着提高放射治疗的疗效，并将副作用降至最低。这种具有刺激激活NIR-II成像引导放射治疗能力的智能纳米平台在未来的精准生物医学中显示出巨大的希望。
更新日期：2022-06-07
中文翻译：
用于肿瘤双模型 NIR-II 光声和荧光成像和精确放射治疗的刺激响应混合囊泡
生物成像引导放射治疗作为精准医学的主流癌症治疗策略之一被广泛研究。然而，具有“永远在线”成像信号的背景噪声和不充分的肿瘤富集限制了疾病的诊断和治疗。在这里，纳米间隙金纳米粒子（AuNNPs）-硫化银（Ag 2 S）囊泡（Ve）通过pH响应性聚合物硫醇化聚苯乙烯-共聚（4-乙烯基吡啶）的自组装被设计为“生物开关”接枝的AuNNPs和Ag 2 S量子点（QDs）。AuNNPs–Ag 2 S Ve 最初表现出猝灭的 NIR-II 荧光 (FL) 和增强的光声信号，可以被酸性环境特异性激活以释放 Ag 2S QD 和在第二个近红外（NIR-II，950–1700 nm）窗口中“打开”NIR-II FL 信号。此外，疾病定位的 NIR-II 成像引导癌症治疗策略可以显着提高放射治疗的疗效，并将副作用降至最低。这种具有刺激激活NIR-II成像引导放射治疗能力的智能纳米平台在未来的精准生物医学中显示出巨大的希望。
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