Body Temperature Enhanced Adhesive, Antibacterial, and Recyclable Ionic Hydrogel for Epidermal Electrophysiological Monitoring,Advanced Healthcare Materials

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Body Temperature Enhanced Adhesive, Antibacterial, and Recyclable Ionic Hydrogel for Epidermal Electrophysiological Monitoring
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2022-06-06 , DOI: 10.1002/adhm.202200653
Ying Liu _{1,

2} , Chan Wang _{1,

2} , Jiangtao Xue _{1,

3} , Guanhua Huang _{4,

5} , Shuang Zheng _{4,

5} , Ke Zhao _{4,

5} , Jing Huang _{1,

6} , Yiqian Wang _{1,

7} , Yan Zhang ₈ , Tailang Yin ₉ , Zhou Li _{1,

2,

6,

10}

Affiliation

CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China.
School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
State Key Laboratory of Brain and Cognitive Science, Institute of psychology, Chinese Academy of Sciences, Beijing, 100101, China.
Department of Psychology, University of the Chinese Academy of Sciences, Beijing, 100049, China.
College of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, China.
College of Mechanical Engineering, Guangxi University, Nanning, 530004, China.
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.

Hydrogel-based epidermal electrodes attract widespread attention in health monitoring and human-machine interfaces for their good biocompatibility, skin-matched Young's modulus, and stable in situ electrophysiological recording performance. However, it is difficult to make the exact conformal attachment between skin and electrodes because of the hair, wrinkles, as well as complex, curved contours of the skin. This also results in signal distortion and large noise. Here, a body temperature enhanced skin-adhesive epidermal electrode is proposed based on non-covalent cross-linked network ionic hydrogel. The ionic hydrogel is fabricated by the polyvinyl alcohol, branched polyethyleneimine, and calcium chloride (CaCl₂), which demonstrates impressive performances including ultra-stretchability of 1291%, great adhesion to skin and other non-biological materials, stable conductivity of 3.09 S m⁻¹, recyclability, and outstanding antibacterial ability, simultaneously. Specifically, the adhesion of the ionic hydrogel behaves as temperature-sensitive and could be enhanced by body temperature. Furthermore, the ionic hydrogel is utilized as epidermal electrodes, which display seductive capability to record multifarious electrophysiological signals with high signal-to-noise ratio and ultra-low detection limit, including electrocardiogram, electromyogram, and electroencephalogram. The as-proposed body temperature enhanced skin-adhesive ionic hydrogel brings intelligent functions and broadens the way for epidermal electronics, promoting the development of healthcare electronics.

中文翻译：

用于表皮电生理监测的体温增强粘合剂、抗菌和可回收离子水凝胶

基于水凝胶的表皮电极以其良好的生物相容性、与皮肤匹配的杨氏模量和稳定的原位电生理记录性能在健康监测和人机界面方面引起了广泛关注。然而，由于头发、皱纹以及复杂的皮肤弯曲轮廓，很难在皮肤和电极之间进行精确的共形连接。这也会导致信号失真和大噪声。在此，提出了一种基于非共价交联网络离子水凝胶的体温增强型皮肤粘附表皮电极。离子水凝胶由聚乙烯醇、支链聚乙烯亚胺和氯化钙（CaCl ₂)，表现出令人印象深刻的性能，包括 1291% 的超拉伸性、对皮肤和其他非生物材料的良好附着力、3.09 S m ^{−1的稳定导电性}，可回收性和出色的抗菌能力，同时。具体来说，离子水凝胶的粘附性表现为温度敏感，可以通过体温增强。此外，离子水凝胶被用作表皮电极，具有诱人的能力，可以记录具有高信噪比和超低检测限的多种电生理信号，包括心电图、肌电图和脑电图。拟研制的体温增强型贴肤离子水凝胶，带来智能化功能，拓宽表皮电子化途径，推动医疗保健电子化发展。

更新日期：2022-06-06

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