具有近红外触发的光热和一氧化氮释放活性的功能化硼纳米片用于有效的抗菌治疗和促进伤口愈合,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

具有近红外触发的光热和一氧化氮释放活性的功能化硼纳米片用于有效的抗菌治疗和促进伤口愈合
Biomaterials Science ( IF 5.8 ) Pub Date : 2022-06-07 , DOI: 10.1039/d2bm00519k
Jialin Lv ₁ , Ye Qi ₁ , Yiming Tian ₁ , Guangyao Wang ₁ , Lei Shi ₁ , Guiling Ning _{1,

2} , Junwei Ye _{1,

2}

Affiliation

细菌耐药性的蔓延对全球公共健康构成日益严重的威胁，迫切需要开发新一代抗菌纳米制剂来替代抗生素。在这项工作中，基于硼纳米片 (B NS) 包覆的季铵化壳聚糖 (QCS) 和一氧化氮 (NO) 供体N , N ' -di- sec -butyl- N , N '-dinitroso-1 的多功能纳米平台， 4-苯二胺 (BNN6) (B-QCS–BNN6) 是通过液相剥离和静电吸附法。2D B NSs可以将近红外（NIR）光转化为热能并组装带正电的QCS和BNN6来捕获带负电的细菌，正电荷使其容易被细菌捕获，增加了NO扩散到细菌表面。B-QCS-BNN6纳米平台不仅表现出光热疗法（PTT）的功效，而且还可以在808 nm激光刺激后精确控制NO的释放，从而快速有效地治疗典型的革兰氏阴性和革兰氏阳性细菌。增强的 PTT/NO 抗菌功能在 5 分钟内实现了 >99.9% 的细菌灭活。此外，金黄色葡萄球菌(MRSA) 感染的伤口和促进受损组织重建用于体内MRSA 感染的伤口治疗。

"点击查看英文标题和摘要"

Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion

The spread of bacterial resistance is a rising serious threat to global public health, and has created an urgent need for the development of a new generation of antibacterial nano-agents to take the place of antibiotics. In this work, a multifunctional nanoplatform based on boron nanosheet (B NS)-coated quaternized chitosan (QCS) and the nitric oxide (NO) donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine (BNN6) (B-QCS–BNN6) was prepared via a liquid-phase exfoliation and electrostatic adsorption method. The 2D B NSs could convert near-infrared (NIR) light into heat energy as well as assemble positively charged QCS and BNN6 to trap negatively charged bacteria, and the positive charge made it easily captured by bacteria, increasing the opportunities for NO diffusion to the bacterial surface. The B-QCS–BNN6 nanoplatform not only exhibited photothermal therapy (PTT) efficacy but could also control NO release precisely after stimulation with an 808 nm laser for the rapid and effective treatment of typical Gram-negative and Gram-positive bacteria. The enhanced PTT/NO antibacterial function achieved >99.9% inactivation of bacteria within 5 min. Furthermore, this synergetic antibacterial strategy could also be conveniently employed for highly efficient disinfection of a methicillin-resistant Staphylococcus aureus (MRSA) infected wound and promotion of the reconstruction of damaged tissues for in vivo MRSA-infected wound therapy.

更新日期：2022-06-07

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南