e18664 Background: Most of the work on PRO has been done in outpatient setting. However, cancer patients might even suffer from more severe problems when admitted to hospital for anticancer therapy. The question whether and how patients’ well-being changes during the course of the hospital stay and if electronically assessed PRO (ePRO) will bring benefit to patients and physicians remains unanswered. Implementing such a tool into routine clinical care can be considered as an additional challenge.The objectives of this study were to implement a multidimensional ePRO system to improve patient-physician interaction in inpatient cancer care and test its feasibility. A comprehensive set of PRO measures that would broadly assess the patient’s situation was developed by a multidisciplinary expert team. Before study initiation, semi-structured interviews with patients were carried out to optimize visualization and user experience. The tool included a rapid response ePRO system with a patient-tailored graphical feedback for physicians. The effect of the mobile tool on quality of life (QoL), symptom burden and patients’ satisfaction with care were explored. Methods: The study is an interventional, three-arm and multicenter inpatient trial. A self-administered questionnaire based on validated PRO-measures was applied and completed at admission, one week after and at discharge. Group A (intervention arm) and B received tablet versions while group C (control) completed the questionnaire on paper. Additional to the mere assessment of electronic patient reported outcome, results from group A were presented graphically to the treating physicians. Standardized instruments included measures of QoL (EORTC QLQ-C30), patients’ satisfaction with care (IN-PATSAT32) and adverse events (PRO-CTCAE). A feasibility questionnaire was administered to arm A and B. Results: N = 185 patients (mean age 63.5, 44.3% female) were recruited in oncology wards. 62% of patients were treated for oncological disease (33% with stage IV disease) and 37% for hematological disease. Feasibility questions revealed that the majority of patients preferred the electronic tool and believed that the tool was of high value for individualized patient care. Among others, symptom burden and global QoL did not significantly change during hospital stay. Satisfaction with care was significantly lower ( p = 0.047) in the intervention group (mean 3.55) versus the control group (mean 3.77) with scores ranging from 0-5. Conclusions: Results indicate that the intervention is feasible. Some of the results are counterintuitive and could possibly be influenced by a lack of physician compliance due to a busy daily routine. Moreover, the optimal interval and composition of questionnaires has yet to be determined in inpatient setting.

中文翻译：

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常规住院癌症护理中患者报告结果 (PRO) 的移动和综合评估：一项三臂随机对照可行性研究。

e18664 背景：PRO 的大部分工作都是在门诊环境中完成的。然而，癌症患者在入院接受抗癌治疗时甚至可能会遇到更严重的问题。住院期间患者的健康状况是否以及如何发生变化以及电子评估 PRO (ePRO) 是否会给患者和医生带来益处的问题仍未得到解答。将这种工具实施到常规临床护理中可被视为一项额外挑战。本研究的目的是实施多维 ePRO 系统，以改善住院癌症护理中的医患互动并测试其可行性。一个多学科专家团队制定了一套全面的 PRO 措施，可以广泛评估患者的情况。开学前，对患者进行半结构化访谈以优化可视化和用户体验。该工具包括一个快速响应的 ePRO 系统，为医生提供为患者量身定制的图形反馈。探讨了移动工具对生活质量 (QoL)、症状负担和患者护理满意度的影响。方法：该研究是一项介入性、三组和多中心住院试验。在入院、一周后和出院时应用并完成了基于经过验证的 PRO 措施的自我管理问卷。A 组（干预组）和 B 组接受平板电脑版本，而 C 组（对照组）完成纸质问卷。除了仅评估电子患者报告的结果外，A 组的结果还以图形方式呈现给治疗医师。标准化工具包括 QoL (EORTC QLQ-C30)、患者对护理的满意度 (IN-PATSAT32) 和不良事件 (PRO-CTCAE) 的测量。对 A 组和 B 组进行了可行性问卷调查。结果：在肿瘤病房招募了 N = 185 名患者（平均年龄 63.5 岁，44.3% 为女性）。62% 的患者接受了肿瘤疾病治疗（33% 为 IV 期疾病），37% 的患者接受了血液疾病治疗。可行性问题表明，大多数患者更喜欢电子工具，并认为该工具对于个性化的患者护理具有很高的价值。其中，症状负担和整体生活质量在住院期间没有显着变化。干预组（平均 3.55）与对照组（平均 3.77）相比，护理满意度显着降低（p = 0.047），评分范围为 0-5。结论：结果表明干预是可行的。一些结果是违反直觉的，并且可能受到由于繁忙的日常生活而缺乏医生依从性的影响。此外，在住院环境中尚未确定问卷的最佳间隔和组成。