Verification of Bound Aminoguanidine as the Marker Residue for the Banned Antibiotic, Nitrovin, in Pig Tissues,Journal of Agricultural and Food Chemistry

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Verification of Bound Aminoguanidine as the Marker Residue for the Banned Antibiotic, Nitrovin, in Pig Tissues
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-06-06 , DOI: 10.1021/acs.jafc.2c00843
Gemma Regan _{1,

2} , Philip Mullen ₃ , Mary Moloney ₁ , Karl De Ruyck ₁ , Terence Fodey ₃ , Sarah E Millar ₃ , Steven Crooks ₃ , Anna Gadaj ₃ , Chris Elliott ₂ , Martin Danaher ₁

Affiliation

Nitrovin (NTV) belongs to a class of antibiotics called nitrofurans, which are classified as nonallowed pharmacologically active substances that do not have a maximum residue limit listed in EU legislation. The objectives of this study were to confirm aminoguanidine (AGN) as a suitable marker residue to monitor NTV abuse and to investigate its persistence in porcine tissues. In this work, pigs were fed with NTV-medicated feed (50 mg/kg), and tissues (kidney, muscle, and liver) and plasma were collected on different withdrawal days. All samples were analyzed for bound AGN, total AGN, and the parent drug NTV itself. The highest concentrations of AGN residues were found in the liver, while the lowest were in muscle. Parent NTV was only detected in the kidney at low levels on day 0 of withdrawal. The findings are in support of using AGN as the marker residue for monitoring the illegal use of NTV in animal-derived products.

中文翻译：

验证结合的氨基胍作为猪组织中禁用抗生素 Nitrovin 的标志物残留

Nitrovin (NTV) 属于一类称为硝基呋喃的抗生素，属于不允许使用的药理活性物质，在欧盟立法中没有列出最大残留限量。本研究的目的是确认氨基胍 (AGN) 作为一种合适的标记物残留物来监测 NTV 滥用并研究其在猪组织中的持久性。在这项工作中，猪饲喂 NTV 药物饲料（50 mg/kg），并在不同的停药日收集组织（肾脏、肌肉和肝脏）和血浆。分析所有样品的结合 AGN、总 AGN 和母体药物 NTV 本身。在肝脏中发现最高浓度的 AGN 残留物，而在肌肉中最低。仅在停药第 0 天在肾脏中检测到低水平的亲本 NTV。

更新日期：2022-06-06

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