Iodine-Promoted N-Acylation of Amines with Hydrazide: An Efficient Metal-Free Amidation,Synthesis

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Iodine-Promoted N-Acylation of Amines with Hydrazide: An Efficient Metal-Free Amidation
Synthesis ( IF 2.2 ) Pub Date : 2022-06-08 , DOI: 10.1055/a-1838-9491
Long Tian ₁ , Qianwei Zhang ₁ , Keyume Ablajan ₁

Affiliation

An efficient protocol for the amidation of hydrazide with amine has been developed by utilizing I₂ as an oxidant under metal- and base-free conditions at room temperature. N-Acylation products of amines were obtained in good to excellent yields without using toxic reagents. This method is operationally straightforward and tolerates aliphatic/aromatic and primary/secondary amines with different hydrazides.

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