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Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2022-06-03 , DOI: 10.1002/adfm.202202470
Xu Xue 1 , Hao Zhang 2 , Han Liu 1 , Sicheng Wang 1 , Jiadong Li 1 , Qirong Zhou 2 , Xiao Chen 2 , Xiaoxiang Ren 1 , Yingying Jing 1 , Yonghui Deng 3 , Zhen Geng 1 , Xiuhui Wang 1 , Jiacan Su 1, 2
Affiliation  

3D-printed polycaprolactone (PCL) scaffolds have been extensively studied for application in bone tissue engineering. However, PCL-based scaffolds with enhanced bioactivity and intelligent delivery capability for bone repair remains challenging. Herein, CuS nanoparticle-PEG soft hydrogel-coated 3D hard polycaprolactone scaffolds (denoted as CuS-PEG-PCL scaffold) are rationally designed for efficient bone regeneration. CuS nanoparticles cross-linked PEG hydrogel (CuS-PEG-hydrogel) endows the PCL-based scaffold with excellent photothermal properties and stable soft elasticity, while the PCL scaffold provides excellent mechanical performance. Upon exposure to 1064 nm near-infrared (NIR) light irradiation, dexamethasone sodium phosphate (Dexp), stored in the CuS-PEG-PCL scaffold, can be controllably released, which efficiently promotes osteogenic differentiation of bone mesenchymal stem cells (BMSCs). In addition, the combination of mild heating at 42 ± 0.5 °C further promoted osteogenic differentiation of BMSCs. Subsequently, this Dexp-loaded CuS-PEG-PCL scaffold (D-CuS-PEG-PCL scaffold) with NIR light treatment at the tibial defect of rats presented the highest bone regeneration capacity. These findings demonstrate that the Dexp-loaded CuS-PEG-hydrogel can effectively modify the 3D printed PCL scaffold. Therefore, this multifunctional scaffold with a soft-hard hybrid structure has the potential to become an advanced drug delivery vehicle in the treatment of large bone defects.

中文翻译:

用于高效骨再生的多功能CuS纳米颗粒-PEG复合软水凝胶涂层3D硬聚己内酯支架的合理设计

3D 打印的聚己内酯 (PCL) 支架已被广泛研究用于骨组织工程。然而,具有增强的生物活性和智能传递能力的基于 PCL 的骨修复支架仍然具有挑战性。在此,CuS 纳米颗粒-PEG 软水凝胶涂层 3D 硬聚己内酯支架(称为 CuS-PEG-PCL 支架)经过合理设计,可实现有效的骨再生。CuS纳米粒子交联PEG水凝胶(CuS-PEG-hydrogel)赋予PCL基支架优异的光热性能和稳定的软弹性,而PCL支架提供优异的机械性能。在暴露于 1064 nm 近红外 (NIR) 光照射后,储存在 CuS-PEG-PCL 支架中的地塞米松磷酸钠 (Dexp) 可以可控地释放,有效促进骨间充质干细胞(BMSCs)的成骨分化。此外,42±0.5°C温和加热的组合进一步促进了骨髓间充质干细胞的成骨分化。随后,这种载有Dexp的CuS-PEG-PCL支架(D-CuS-PEG-PCL支架)在大鼠胫骨缺损处进行了近红外光处理,表现出最高的骨再生能力。这些发现表明,负载 Dexp 的 CuS-PEG-水凝胶可以有效地修饰 3D 打印的 PCL 支架。因此,这种具有软硬混合结构的多功能支架有可能成为治疗大骨缺损的先进药物输送载体。随后,这种载有Dexp的CuS-PEG-PCL支架(D-CuS-PEG-PCL支架)在大鼠胫骨缺损处进行了近红外光处理,表现出最高的骨再生能力。这些发现表明,负载 Dexp 的 CuS-PEG-水凝胶可以有效地修饰 3D 打印的 PCL 支架。因此,这种具有软硬混合结构的多功能支架有可能成为治疗大骨缺损的先进药物输送载体。随后,这种载有Dexp的CuS-PEG-PCL支架(D-CuS-PEG-PCL支架)在大鼠胫骨缺损处进行了近红外光处理,表现出最高的骨再生能力。这些发现表明,负载 Dexp 的 CuS-PEG-水凝胶可以有效地修饰 3D 打印的 PCL 支架。因此,这种具有软硬混合结构的多功能支架有可能成为治疗大骨缺损的先进药物输送载体。
更新日期:2022-06-03
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