当前位置：
X-MOL 学术
›
Org. Lett.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Chloride Transport across Liposomes and Cells by Nontoxic 3-(1H-1,2,3-Triazol-1-yl)benzamides
Organic Letters ( IF 4.9 ) Pub Date : 2022-06-03 , DOI: 10.1021/acs.orglett.2c01219 Javid Ahmad Malla 1 , Avisikta Upadhyay 1 , Pulak Ghosh 1 , Debashis Mondal 1 , Abhishek Mondal 1 , Shilpy Sharma 2 , Pinaki Talukdar 1
Organic Letters ( IF 4.9 ) Pub Date : 2022-06-03 , DOI: 10.1021/acs.orglett.2c01219 Javid Ahmad Malla 1 , Avisikta Upadhyay 1 , Pulak Ghosh 1 , Debashis Mondal 1 , Abhishek Mondal 1 , Shilpy Sharma 2 , Pinaki Talukdar 1
Affiliation
|
Synthetic anion transmembrane transporters are adding new aspirations for treating channelopathies by replacing defective ion channels. The availability of such suitable candidates is still infrequent due to the associated toxicity. Here, we report 3-(1H-1,2,3-triazol-1-yl)benzamides as transmembrane anion carriers, nontoxic to cells. The selective and electrogenic chloride transport activity was established by fluorescence and ion selective electrode-based assays. MQAE assay confirmed the chloride uptake into the cells by the nontoxic compounds.
中文翻译：
无毒 3-(1H-1,2,3-Triazol-1-yl) 苯甲酰胺在脂质体和细胞中的氯化物转运
合成阴离子跨膜转运蛋白通过替换有缺陷的离子通道为治疗通道病增添了新的希望。由于相关的毒性，此类合适候选物的可用性仍然很少。在这里，我们报告了 3-(1 H -1,2,3-triazol-1-yl)benzamides 作为跨膜阴离子载体，对细胞无毒。通过基于荧光和离子选择性电极的测定确定选择性和电生成氯化物转运活性。MQAE 测定证实无毒化合物将氯化物吸收到细胞中。
更新日期：2022-06-03
中文翻译：
无毒 3-(1H-1,2,3-Triazol-1-yl) 苯甲酰胺在脂质体和细胞中的氯化物转运
合成阴离子跨膜转运蛋白通过替换有缺陷的离子通道为治疗通道病增添了新的希望。由于相关的毒性，此类合适候选物的可用性仍然很少。在这里，我们报告了 3-(1 H -1,2,3-triazol-1-yl)benzamides 作为跨膜阴离子载体，对细胞无毒。通过基于荧光和离子选择性电极的测定确定选择性和电生成氯化物转运活性。MQAE 测定证实无毒化合物将氯化物吸收到细胞中。
京公网安备 11010802027423号