In elderly aged people, Parkinson's disease is reported as 2nd most prevailing neuro-degenerative disease. Presently benzothiazole derivatives are gaining attention after showing positive results in various animal models for the investigation of different motor-diseases. In Current work, the 2- (2 Thienyl)Benzothiazoline is synthesized and its therapeutic effect was evaluated against rotenone-induced Parkinson's disease. It was expected to obtain the positive results in the treatment because thiophen group has been successfully reported in various literature as effective agent in the treatment of cognitive and locomotory disease. So, we used a Parkinson's inducive compound rotenone and injectedit intraperitoneally. The dose that we were used was 1.5mg/kg and treatment proceeded for 8 days in rats as rotenone inhibit the functioning of mitochondrial complex I. Administration of 2- (2 Thienyl)Benzothiazoline (10mg/kg per day) was already started 15 days prior to rotenone dose injection. The effects of both pre-treatment and without pre-treatment of 2- (2 Thienyl)Benzothiazoline were assessed by the use of various motor parameters of behavior such as pole test and Kondziela's inverted screen test for checking muscular strength, whereas inclined plane test, open field test and Rota rod test for motor coordination. Pre-treatment with drug reversed the gross motor impairments which were produced by rotenone. We conclude that 2- (2 Thienyl)Benzothiazoline, like its other candidate drug also protects against destructive effects of the compound rotenone and itcan be used as beneficial drug against various neurodegenerative diseases.

中文翻译：

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2-（2-噻吩基）苯并噻唑啉对鱼藤酮诱导的帕金森病大鼠模型的粗大运动技能缺陷的神经保护作用。

据报道，在老年人中，帕金森病是第二大流行的神经退行性疾病。目前苯并噻唑衍生物在用于研究不同运动疾病的各种动物模型中显示出积极结果后受到关注。在目前的工作中，合成了 2-（2 噻吩基）苯并噻唑啉，并评估了其对鱼藤酮诱导的帕金森病的治疗效果。由于噻吩组已在各种文献中成功报道为治疗认知和运动疾病的有效药物，因此有望在治疗中获得积极的结果。因此，我们使用了一种帕金森氏诱导复合鱼藤酮并腹腔注射。我们使用的剂量是 1。由于鱼藤酮抑制线粒体复合物I的功能，5mg/kg在大鼠中进行了8天的治疗。在鱼藤酮剂量注射前15天已经开始施用2-(2噻吩基)苯并噻唑啉(每天10mg/kg)。2-(2 噻吩基)苯并噻唑啉预处理和未预处理的效果通过使用各种运动行为参数进行评估，例如用于检查肌肉力量的杆测试和 Kondziela 的倒置屏幕测试，而斜面测试，用于运动协调的开放现场测试和旋转棒测试。药物预处理逆转了由鱼藤酮产生的粗大运动障碍。我们得出的结论是 2- (2 Thienyl)Benzothiazoline,