After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

中文翻译：

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一种实用且可扩展的氟取代双环[1.1.1]戊烷方法

经过 20 多年的试验，已开发出一种实用的可扩展方法来制备氟代双环 [1.1.1] 戊烷 (F-BCP)。对 F-BCPs 的理化性质进行了研究，并将核心纳入抗炎药氟比洛芬的结构中，以代替氟苯环。