Abstract

A simple synthetic approach has been developed for the enantioselective total synthesis of (+)-Sedridine, (-)-Allosedridine and their analogs such as (+)-N- Methyl Sedridine and (-)-N-Methylallosedridine. The synthesis was achieved by using commercially available starting materials via Maruoka-Keck allylation, Wacker oxidation, and CBS reduction. The synthetic root provides a good diastereomeric ratio and high yields.

中文翻译：

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通过 Maruoka-Keck 烯丙基化和 CBS 还原对映选择性合成 (+)-Sedridine、(-)-Alloseridine 及其 N-甲基类似物

摘要

开发了一种简单的合成方法，用于对映选择性全合成 (+)-Sedridine、(-)-Allosedridine 及其类似物，如 (+)- N-甲基 Sedridine 和 (-)- N -Mmethylallosedridine。该合成是使用市售起始材料通过Maruoka-Keck 烯丙基化、瓦克氧化和 CBS 还原来实现的。合成根提供良好的非对映体比例和高产量。