Larrea tridentata antibacterial lignan 4,4′-dihydroxy-3-methoxy-6,7′-cyclolignan (1) was derivatized to obtain eleven new amino ether derivatives (2 A-12 C). The structural elucidation of compounds was performed by analysis of 1D- and 2D NMR spectral data and HRESIMS. The antibacterial activity of compounds was determined against nine drug-resistant bacteria and two strains of Mycobacterium tuberculosis (sensitive ATCC 27294 H37Rv and drug-resistant G122). Results showed that all derivatives were devoid of activity towards six gram-negative clinical isolates assayed. However, seven derivatives displayed antibacterial activity against three gram-positive drug-resistant bacteria. Further, enhancement of antibacterial activity was only observed for the compounds 2 A and 10 C-12 C (MIC of 12.5 µg/mL) which were two-fold more active than the starting material 1 against vancomycin-resistant Enterococcus faecium. All derivatives, except compound 9 B, showed antitubercular activity against both M. tuberculosis strains. Interestingly, all the compounds, except for 2 A and 11 A, were more active than the starting material 1 (MIC of 50 µg/mL). Compound 4 C was the only compound as active as the positive control ethambutol against the drug-resistant strain M. tuberculosis G122 (MIC of 6.25 µg/mL). In addition, the derivative 7 C was the most active compound against the sensitive strain M. tuberculosis H37Rv (MIC of 6.25 µg/mL)

Larrea tridentata抗菌木脂素4,4'-二羟基-3-甲氧基-6,7'-环木脂素( 1 )经衍生得到十一种新的氨基醚衍生物( 2A - 12C )。通过分析 1D 和 2D NMR 光谱数据和 HRESIMS 进行化合物的结构解析。化合物对九种耐药菌和两种结核分枝杆菌的抗菌活性测定（敏感的 ATCC 27294 H37Rv 和耐药 G122）。结果表明，所有衍生物对所测定的六种革兰氏阴性临床分离株均无活性。然而，七种衍生物对三种革兰氏阳性耐药菌表现出抗菌活性。此外，仅观察到化合物2A和10C-12C(MIC为12.5μg/mL)的抗菌活性增强，其对耐万古霉素的屎肠球菌的活性是起始材料1的两倍。除化合物9 B外，所有衍生物均显示出对结核分枝杆菌的抗结核活性菌株。有趣的是，除了2 A和11 A之外，所有化合物的活性都高于起始材料1（MIC 为 50 µg/mL）。化合物4 C是唯一与阳性对照乙胺丁醇对耐药菌株M. tuberculosis G122 具有活性的化合物（MIC 为 6.25 µg/mL）。此外，衍生物7 C是对敏感菌株M. tuberculosis H37Rv 最有效的化合物（MIC 为 6.25 µg/mL）