用于制药领域生物材料的生物可降解和生物基聚合物的制造,Journal of Applied Polymer Science

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用于制药领域生物材料的生物可降解和生物基聚合物的制造
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2022-05-24 , DOI: 10.1002/app.52624
Tariq Aziz ₁ , Asmat Ullah ₂ , Amjad Ali ₃ , Muhammad Shabeer ₁ , Muhammad Naeem Shah ₄ , Fazal Haq ₅ , Mudassir Iqbal ₆ , Roh Ullah ₇ , Farman Ullah Khan ₈

Affiliation

近年来，生物基聚合物已成为各个行业中石油基聚合物的替代品。生物基材料由源自天然来源的原材料制成，例如淀粉、纤维素、甲壳质或可生物降解的合成聚合物（即聚己内酯和聚乳酸）。尽管可生物降解聚合物具有若干理想的特性，例如，完全可再生、无毒。一些特性，如熔体和冲击强度、热稳定性、渗透性等，仍然不能满足最终用途的要求。改善生物聚合物性能并大大提高其商业潜力的一种方法是在聚合物中加入纳米级增强材料。纳米载体对智能聚合物和生物材料的访问受到聚合方法的限制。生物聚合物被认为是石油基纤维的替代品。这些是由生物直接产生的。智能纳米颗粒用于不同的药物，其应用取决于尺寸。在用于纳米粒子之间的灵敏度、选择性和相互作用的不同技术中。更重要的是，发现了不同的聚合方法。详细讨论了制药领域中纳米凝胶的制备、生物可降解和生物聚合物制造等方法。还强调了它们在基因传递、智能成像和多价方法中的应用、特性。在用于纳米粒子之间的灵敏度、选择性和相互作用的不同技术中。更重要的是，发现了不同的聚合方法。详细讨论了制药领域中纳米凝胶的制备、生物可降解和生物聚合物制造等方法。还强调了它们在基因传递、智能成像和多价方法中的应用、特性。在用于纳米粒子之间的灵敏度、选择性和相互作用的不同技术中。更重要的是，发现了不同的聚合方法。详细讨论了制药领域中纳米凝胶的制备、生物可降解和生物聚合物制造等方法。还强调了它们在基因传递、智能成像和多价方法中的应用、特性。

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Manufactures of bio-degradable and bio-based polymers for bio-materials in the pharmaceutical field

In recent years, bio-based polymers have emerged as an alternative to petroleum-based polymers in various industries. The bio-based materials are made from raw materials originating from natural sources, such as starch, cellulose, chitin, or bio-degradable synthetic polymers (i.e., polycaprolactone and polylactic acid). In spite of several desirable properties of biodegradable polymers, for example, fully renewable, non-toxic. Some properties like melt and impact strength, thermal stability, permeability, and so forth, still do not meet the demands for end-use applications. One way to improve the properties of biopolymers and greatly enhance their commercial potential is to incorporate nanosized reinforcement in the polymer. The access of nano-carriers to smart polymeric and bio-materials are limited by polymerization methods. Bio-polymers are considered an alternative to petroleum-based fibers. These are directly produced by organisms. Smart nanoparticles are used in different medicines and their applications are size-dependent. Among the different techniques used for sensitivity, selectivity, and interactions among the nanoparticles. More so, different approaches were found for polymerization. Methodologies such as the preparation of nano-gels, bio-degradable, and bio-polymers manufacturing in the pharmaceutical field are discussed in detail. Their applications, properties in gene delivery, smart imaging, and multivalency approach are also highlighted.

更新日期：2022-05-24

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