Halogen-Bonding-Promoted C–H Malonylation of Indoles under Visible-Light Irradiation,The Journal of Organic Chemistry

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Halogen-Bonding-Promoted C–H Malonylation of Indoles under Visible-Light Irradiation
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2022-05-25 , DOI: 10.1021/acs.joc.2c00413
Xuebo Gao ₁ , Rong Chang ₂ , Junxin Rao ₃ , Danyang Hao ₁ , Zhuxia Zhang ₁ , Cong-Ying Zhou ₃ , Zhen Guo ₁

Affiliation

Herein, we report a halogen-bonding-based electron donor–acceptor (EDA) complex-promoted photoreaction for the synthesis of C2-malonylated indoles. The protocol provides access to a broad range of functionalized indoles in good yields through the coupling reaction of indoles with diethyl bromomalonate under visible-light irradiation without the need for any transition-metal catalyst or photocatalyst.

中文翻译：

可见光照射下卤素键促进吲哚的 C-H 丙二酰化

在此，我们报告了一种基于卤素键的电子供体 - 受体 (EDA) 复合物促进的光反应，用于合成 C2-丙二酰化吲哚。该协议通过吲哚与溴丙二酸二乙酯在可见光照射下的偶联反应，无需任何过渡金属催化剂或光催化剂，即可以良好的收率获得广泛的功能化吲哚。

更新日期：2022-05-25

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