Abstract Hydroxyapatite has good stability, biological activity and biocompatibility, the calcium ions can be a variety of metal ions by ion exchange reaction, form M apatite of the corresponding metal ions (M on behalf of metal ions that replace calcium). Hydroxyapatite also has a good ability of bone conduction, bio decomposition and bone formation induction, make it an excellent and nearly ideal repair and replacement material for human teeth and bones when damaged. However, due to its low strength, poor toughness, difficult to form, poor corrosion resistance, hydroxyapatite has not been widely used. Therefore, the preparation of hydroxyapatite with superior comprehensive properties and more ideal composite materials has become the focus of research in recent years. This article is written based on the research status of hydroxyapatite, summarizing the origin, development, preparation, application and development prospect of hydroxyapatite. Emphatically analyzing the advantages and disadvantages of three common methods, including hydrothermal method, solvothermal method and homogeneous precipitation method, the structure, size, properties and application of hydroxyapatite obtained using these methods are also discussed. Views on the future development prospect and research direction of hydroxyapatite are also put forward.

中文翻译：

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羟基磷灰石的三种常见制备方法

摘要羟基磷灰石具有良好的稳定性、生物活性和生物相容性，其钙离子可与多种金属离子进行离子交换反应，形成相应金属离子的M磷灰石（M代表取代钙的金属离子）。羟基磷灰石还具有良好的骨传导、生物分解和骨形成诱导能力，使其成为人类牙齿和骨骼受损时极佳且近乎理想的修复和替代材料。但由于羟基磷灰石强度低、韧性差、成型困难、耐腐蚀性差，尚未得到广泛应用。因此，制备综合性能优越、更理想的复合材料羟基磷灰石成为近年来研究的热点。本文根据羟基磷灰石的研究现状，对羟基磷灰石的起源、发展、制备、应用及发展前景进行了综述。重点分析了水热法、溶剂热法和均匀沉淀法三种常用方法的优缺点，并对这些方法所得羟基磷灰石的结构、尺寸、性能和应用进行了讨论。并对羟基磷灰石的未来发展前景和研究方向提出了看法。