Water-soluble diphosphine ligands for rhodium-catalyzed branch-selective hydroaminomethylation of vinyl arenes with anilines in water,Green Chemistry

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Water-soluble diphosphine ligands for rhodium-catalyzed branch-selective hydroaminomethylation of vinyl arenes with anilines in water
Green Chemistry ( IF 9.3 ) Pub Date : 2022-05-24 , DOI: 10.1039/d2gc00802e
Luyun Zhang _{1,

2,

3} , Yingtang Ning _{1,

2} , Baijun Ye _{1,

2} , Tong Ru _{1,

2} , Fen-Er Chen _{1,

2,

3}

Affiliation

Rhodium-catalyzed hydroaminomethylation of various vinyl arenes with anilines has been accomplished using water as an environmentally benign reaction media. This aqueous reaction is facilitated by the water-soluble diphosphine ligands derived from bis(2-(diphenylphosphaneyl)ethyl)amides. The methodology demonstrated a broad scope of substrates and accessed the N-(2-phenylpropyl)anilines in good yields (up to 94%) and high selectivities. Mechanistic studies with a series of competition experiments and isotope labeling revealed the imine hydrogenation reactivity of the catalysts.

中文翻译：

水溶性二膦配体用于铑催化的乙烯基芳烃与苯胺在水中的支链选择性加氢氨基甲基化反应

各种乙烯基芳烃与苯胺的铑催化氢氨基甲基化反应已经使用水作为环境友好的反应介质来完成。衍生自双(2-(二苯基膦基)乙基)酰胺的水溶性二膦配体促进了这种水性反应。该方法展示了广泛的底物范围，并以良好的收率（高达 94%）和高选择性获得了N-（2-苯丙基）苯胺。一系列竞争实验和同位素标记的机理研究揭示了催化剂的亚胺加氢反应性。

更新日期：2022-05-24

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